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Tests treatment safety and results for Abdominal Aortic Aneurysm
Official title Safety and Efficacy of Endovascular Repair of Complex Aortic Pathology With Physician-modified Endovascular Grafts (PMEGs)
ClinicalTrials.gov ID: NCT04746677
What this study is testing
- What it's testing
- The primary objective of this study is to examine the safety and effectiveness of physician-modified endovascular grafts (PMEGs) for endovascular repair of complex aortic pathology in high-risk patients. The study is divided into three study arms based on the subject's aortic pathology: (1) Complex abdominal aortic aneurysm (AAA); (2) Thoracoabdominal aortic aneurysm; and (3) Aortic dissection.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 and older
You may be able to join if
- General (applicable to all 3 study arms):
- Aortic pathology that fits one of the study arms (see below for detailed description)
- Aortic pathology that cannot be treated within the Instructions for Use of an FDA- approved, commercially-available device
- Aortic aneurysm that can be treated within the Instructions for Use of an FDA-approved, commercially-available custom-manufactured device but deemed...
- Subject is at high-risk of morbidity and mortality with open surgical repair based on cardiopulmonary function, extent of comorbid disease, and...
You likely can't join if
- of Arms 1 - 3
- Patient has prohibitive operative risk for open repair and no other viable endovascular treatment option
- Estimated perioperative risk is lower than the estimated 1-year mortality without surgery EXCLUSION CRITERIA: General Exclusion Criteria
- Subject is eligible for enrollment in a manufacturer-sponsored IDE at the investigational site
- Subject is unwilling to comply with the follow-up schedule
- Inability or refusal to give informed consent by subject or legal representative
See the full eligibility criteria
Who can join
- General (applicable to all 3 study arms):
- Aortic pathology that fits one of the study arms (see below for detailed description)
- Aortic pathology that cannot be treated within the Instructions for Use of an FDA- approved, commercially-available device
- Aortic aneurysm that can be treated within the Instructions for Use of an FDA-approved, commercially-available custom-manufactured device but deemed unsafe to wait the required time for device manufacturing
- Subject is at high-risk of morbidity and mortality with open surgical repair based on cardiopulmonary function, extent of comorbid disease, and anatomic complexity
- Iliac and/or femoral access vessel morphology that is compatible with vascular access techniques, devices, or accessories, with or without use of a surgical or endovascular conduit
- Non-aneurysmal aortic segment proximal to the aortic pathology with a:
- Minimum neck length of 20 mm
- Diameter between 20 - 42 mm
- Non-aneurysmal aortic or iliac segment distal to the aortic pathology with:
- Aortic distal fixation site greater than 20 mm in length and diameter between 20-42 mm
- Iliac artery distal fixation site greater than 10 mm in length and diameter range 8- 25 mm
- Age ≥21 years old
- Life expectancy: ≥2 years Arm1:
- Complex abdominal aortic aneurysm, specifically juxtarenal or suprarenal abdominal aortic aneurysm or type IV thoracoabdominal aortic aneurysm, with maximum diameter of ≥5.5 cm for men or ≥5.0 cm for women, growth ≥0.5...
- Prior endovascular aortic aneurysm repair with loss of proximal seal requiring incorporation of the renal arteries, SMA, and/or CA for repair, without aneurysmal disease extending above the diaphragmatic hiatus
- Prior open abdominal aortic aneurysm repair with aneurysmal disease proximal to the repair requiring incorporation of the renal arteries, SMA, and/or CA for repair, without aneurysmal disease above the diaphragmatic...
- Saccular complex abdominal aortic aneurysm deemed at significant risk for rupture
- Symptomatic complex aortic aneurysm
- Penetrating aortic ulcer with depth ≥1 cm or width ≥2 cm, for which endovascular repair requires incorporation of the renal arteries, SMA, and/or CA, without involvement of the aorta above the diaphragmatic hiatus
- Aortic pseudoaneurysm for which endovascular repair requires incorporation of the renal arteries, SMA, and/or CA, without involvement of the aorta above the diaphragmatic hiatus Arm2:
- Type I, II, or III thoracoabdominal aortic aneurysm with maximum diameter of ≥5.5 cm, or growth ≥0.5 cm in 6 months
- Prior endovascular aortic aneurysm repair with loss of proximal seal requiring incorporation of the renal arteries, SMA, and/or CA for repair with aneurysmal disease extending above the diaphragmatic hiatus
- Prior thoracic endovascular aneurysm repair with loss of distal seal requiring incorporation of the renal arteries, SMA, and/or CA for repair
- Prior open abdominal aortic aneurysm repair with aneurysmal disease proximal to the repair requiring incorporation of the renal arteries, SMA, and/or CA for repair, with aneurysmal disease above the diaphragmatic hiatus
- Saccular type I, II, or III thoracoabdominal aortic aneurysm deemed at significant risk for rupture
- Symptomatic type I, II, or III thoracoabdominal aortic aneurysm
- Penetrating aortic ulcer with depth ≥1 cm or width ≥2 cm, for which endovascular repair requires incorporation of the renal arteries, SMA, and/or CA, with involvement of the aorta above the diaphragmatic hiatus
- Aortic pseudoaneurysm for which endovascular repair requires incorporation of the renal arteries, SMA, and/or CA, with involvement of the aorta above the diaphragmatic hiatus Arm 3:
- Acute or chronic type B aortic dissection with indication for repair including, but not limited to renal, mesenteric, or lower extremity malperfusion, progression of dissection, or persistence of symptoms despite...
- Prior repair of type A dissection and development of acute or chronic type B dissection component with indication for repair (listed above)
- Aortic intramural hematoma (IMH) with indication for repair including, but not limited to renal, mesenteric, or lower extremity malperfusion, progression of dissection, or more typically, persistence of symptoms despite...
- Patient does not meet the inclusion/
What rules you out
- of Arms 1 - 3
- Patient has prohibitive operative risk for open repair and no other viable endovascular treatment option
- Estimated perioperative risk is lower than the estimated 1-year mortality without surgery EXCLUSION CRITERIA: General Exclusion Criteria
- Subject is eligible for enrollment in a manufacturer-sponsored IDE at the investigational site
- Subject is unwilling to comply with the follow-up schedule
- Inability or refusal to give informed consent by subject or legal representative
- Subject is pregnant or breastfeeding
- Subject has a ruptured aneurysm Arm 5 Patient meets criteria for Arms 1-4 \- Patient is undergoing repair using the TREO bifurcated stent graft Indications for using TREO bifurcated stent graft:
- Patient has undergone a prior endovascular aortic repair and meets criteria for repair; OR
- -Patient has measured length from the lowest renal artery to the aortic bifurcation (either de novo or from a prior endograft) \< 115 mm; OR
- In patients with notable vessel tortuosity, where centerline measurement may not accurately reflect the distance covered needed in situ; OR
- Additional clinical or anatomic scenarios where forthcoming experience may demonstrate the TREO endograft to be superior to the currently-used Alpha/Alpha 2 endograft. Medical Exclusion Criteria
- Known sensitivities or allergies to the materials of construction of the devices
- Known hypersensitivity or contraindication to anticoagulation or contrast media that cannot be adequately medically managed
- Uncorrectable coagulopathy
- Body habitus that would inhibit x-ray visualization of the aorta or exceeds the safe capacity of the equipment
- Systemic or local infection that may increase the risk of endovascular graft infection
- Diagnosis of connective tissue disorders (e.g., Marfan Syndrome, Ehler's Danlos Syndrome) Anatomic Exclusion Criteria
- Inability to perform open or endovascular iliac conduit in patients with inadequate femoral/iliac access
- Excessive thrombus or calcification within the neck of the aneurysm
- Visceral vessel anatomy not compatible with placement of a physician-modified endovascular graft due to occlusive disease or small size
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.