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New treatment option for PreDiabetes
Official title Mechanisms for Activation of Beige Adipose Tissue in Humans
ClinicalTrials.gov ID: NCT04666636
What this study is testing
What is Mirabegron?
Mirabegron is an investigational medicine, given as an once-daily injection under the skin, being studied as a potential treatment for prediabetes.
Also referred to as Myrbetriq.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 35 to 65. Healthy volunteers may be eligible.
You may be able to join if
- BMI 27-45
- prediabetes (A1c 5.7-6.4)
- impaired fasting glucose or impaired glucose tolerance
You likely can't join if
- diabetes
- chronic use of anti-diabetic medication
- acute or chronic inflammatory condition
- unstable medical condition
- cancer
- renal insufficiency
See the full eligibility criteria
- BMI 27-45
- prediabetes (A1c 5.7-6.4)
- impaired fasting glucose or impaired glucose tolerance
- diabetes
- chronic use of anti-diabetic medication
- acute or chronic inflammatory condition
- unstable medical condition
- cancer
- renal insufficiency
- any contraindication for Mirabegron
- BMI \>45
The study team makes the final eligibility decision.
Where it's taking place
- Lexington, Kentucky, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 35 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lexington, Kentucky, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.