BridgeMD
New treatment option for Repeated Implantation Failure
Official title Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF
ClinicalTrials.gov ID: NCT04533295
What this study is testing
- What it's testing
- The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 40, women only
You may be able to join if
- Married women aged 25-40;
- Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical...
- Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
- Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.
You likely can't join if
- Patients who met any of the following conditions were not included.
- Those who prepare for PGD;
- Recipients of egg donors;
- Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
- patients with implantation failure due to known embryonic factors;
- Uterine lesions that may affect implantation (including uterine malformation, \>4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine...
See the full eligibility criteria
- Married women aged 25-40;
- Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);
- Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
- Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.
- Patients who met any of the following conditions were not included.
- Those who prepare for PGD;
- Recipients of egg donors;
- Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
- patients with implantation failure due to known embryonic factors;
- Uterine lesions that may affect implantation (including uterine malformation, \>4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc.
- Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation);
- Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months;
- Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.;
- Hydrosalpinx untreated;
- BMI less than 18 or higher than 25kg/m2;
- People with previous history of needle sickness;
- Those who have previously participated in this study or received acupuncture treatment in the past 3 months.
- Any situation that researchers consider inappropriate for participating in this study.
The study team makes the final eligibility decision.
Where it's taking place
- Wuhan, Hubei, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 25 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhan, Hubei, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.