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Prevention study for Subarachnoid Hemorrhage
Official title Prevention of Vasospasm in SAH Through CSF Treatment
ClinicalTrials.gov ID: NCT04490161
What this study is testing
- What it's testing
- The pathophysiological mechanisms of aneurysmal subarachnoid haemorrhage (aSAH) involve early brain injury (EBI) and delayed cerebral ischemia (DCI). Several mechanisms contribute to EBI pathogenesis, including cell death, inflammatory response, oxidative stress, excitotoxicity, microcirculatory dysfunction, microthrombosis and cortical spreading depolarization.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90
You may be able to join if
- Age: \>18, \<90
- SAH HH 3 - 5
- Cerebral saccular Aneurysm
- Digital subtraction angiography prior to aneurysm repair
- Aneurysm repair within 72h
You likely can't join if
- Non-aneurysmal SAH
- SAH HH\<3
- Extensive intraventricular haemorrhage (unable to obtain CSF without massive aspiration of clotted blood)
- Contraindication for digital subtraction angiography
- Aneurysm repair \>72h after rupture
- Signs of radiographic vasospasm upon diagnosis
See the full eligibility criteria
- Age: \>18, \<90
- SAH HH 3 - 5
- Cerebral saccular Aneurysm
- Digital subtraction angiography prior to aneurysm repair
- Aneurysm repair within 72h
- Modified Fisher Grade 3+4
- Presence of aneurysm needing treatment (clipping or coiling)
- Treatment within 24 hours of symptom onset
- External ventricular drain (clinical need)
- Non-aneurysmal SAH
- SAH HH\<3
- Extensive intraventricular haemorrhage (unable to obtain CSF without massive aspiration of clotted blood)
- Contraindication for digital subtraction angiography
- Aneurysm repair \>72h after rupture
- Signs of radiographic vasospasm upon diagnosis
- Presence of systemic or CSF infection
- Contraindication for oral Nimodipin
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Innsbruck, Tyrol, Austria
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Innsbruck, Tyrol, Austria. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.