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New treatment option for Child, Only
Official title Metabolic and Hemodynamic Reserve in Pediatric SCA
ClinicalTrials.gov ID: NCT04406818
What this study is testing
What is Carbon Dioxide?
Carbon Dioxide is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for child, only.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 4 to 21. Healthy volunteers may be eligible.
You may be able to join if
- Healthy Controls:
- Healthy controls ages 4-21 years of age
- Able to participate in MRI scan without sedation
- Not currently pregnant
- No significant psychiatric history, defined as having a severe psychiatric diagnosis, per PI discretion
See the full eligibility criteria
- Healthy Controls:
- Healthy controls ages 4-21 years of age
- Able to participate in MRI scan without sedation
- Not currently pregnant
- No significant psychiatric history, defined as having a severe psychiatric diagnosis, per PI discretion
- No history of epilepsy
- No history of stroke or cerebrovascular disease
- May have occasional headaches if not taking a daily preventative medication for headaches
- Not on vasodilatory medication, such as sildenafil or verapamil Sickle Cell Anemia Participants:
- Ages 4-21 years of age
- Hb SS or SBeta-thal
- Able to participate in MRI scan without sedation
- Not currently pregnant
- Not on vasodilatory medication, such as sildenafil or verapamil
- No known vasculopathy
The study team makes the final eligibility decision.
Where it's taking place
- St Louis, Missouri, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 4 years to 21 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include St Louis, Missouri, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.