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New treatment option for Ocular Hypertension
Official title Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects
ClinicalTrials.gov ID: NCT04401982
What this study is testing
What is Rocklatan (Netarsudil 0.02%/ latanoprost 0.005)?
Rocklatan (Netarsudil 0.02%/ latanoprost 0.005) is an investigational medicine, being studied as a potential treatment for ocular hypertension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to compare participants treated with latanoprost to those treated with Rocklatan (netarsudil/latanoprost) to determine whether the addition of netarsudil results in greater improvements in episcleral venous blood flow in adults with glaucoma or ocular hypertension. Episcleral venous blood flow will be measured using erythrocyte-mediated angiography (EMA) and laser speckle contrast imaging (LSCI).
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Inclusion:
- Patients are at least 18 years of age.
- Patients must have ocular hypertension or be a glaucoma suspect.
- Patient must not have used any IOP-lowering medication (topical or systemic) within the past 6 months
- Patients must have open angles on gonioscopy.
See the full eligibility criteria
- Inclusion:
- Patients are at least 18 years of age.
- Patients must have ocular hypertension or be a glaucoma suspect.
- Patient must not have used any IOP-lowering medication (topical or systemic) within the past 6 months
- Patients must have open angles on gonioscopy.
- All patients will have at least one recorded visual field examination within 6 months of enrollment in the study. Visual fields will be assessed using the Hodapp-Andersen-Parish criteria. Exclusion:
- Participation in other investigational studies, unless such participation does not involve the administration of any drugs or agents that could impact the results of this study or have an effect on episcleral flow, as...
- Prior intraocular surgery other than uncomplicated cataract surgery.
- Allergy or history of adverse reaction to ICG, shellfish, or Iodine.
- Significant liver disease or uremia.
- Secondary glaucoma including exfoliation glaucoma, pigmentary glaucoma, or history of acute angle closure.
- Moderate or severe visual field deficits as per Hodapp-Anderson-Parish criteria.
- Any condition precluding imaging including reliable visual fields, disc photography, or use of study treatments including media opacity or tilted optic disk
- Pregnant or nursing patients.
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
- Columbia, Maryland, United States
- Silver Spring, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States; Columbia, Maryland, United States; Silver Spring, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.