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New treatment option for Body Dysmorphic Disorder
Official title Perceptual Abnormalities and Their Malleability in BDD
ClinicalTrials.gov ID: NCT04373629
What this study is testing
- What it's testing
- A core symptom of body dysmorphic disorder (BDD) is perceptual distortions for appearance, which contributes to poor insight and delusionality, limits engagement in treatment, and puts individuals at risk for relapse. Results from this study will provide a comprehensive mechanistic model of brain, behavioral, and emotional contributors to abnormal perceptual processing, as well as how malleable it is with visual modulation techniques.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Body dysmorphic disorder: Inclusion:
- males or females
- ages 18-40
- meet Diagnostic and Statistical Manual-5 (DSM-5) criteria for Body Dysmorphic Disorder
- have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20
You likely can't join if
- Body dysmorphic disorder: Exclusion
- concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders, as these comorbidities are...
- lifetime: bipolar disorder or psychotic disorder.
- psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but...
- current cognitive-behavioral therapy Exclusion: Subclinical body dysmorphic disorder: Exclusion
- meet full DSM-5 criteria for Body Dysmorphic Disorder
See the full eligibility criteria
- Body dysmorphic disorder: Inclusion:
- males or females
- ages 18-40
- meet Diagnostic and Statistical Manual-5 (DSM-5) criteria for Body Dysmorphic Disorder
- have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20
- primary appearance concerns of the face or head area
- medication naïve or medication free for at least 8 weeks prior to enrollment Subclinical body dysmorphic disorder: Inclusion:
- males or females
- ages 18-40
- have a score on the Dysmorphic Concern Questionnaire of ≥8 [1 standard deviation (STD) above population norms] - primary appearance concerns of the face or head area
- medication naïve or medication free for at least 8 weeks prior to enrollment Healthy controls: Inclusion
- Healthy males and females from any racial or ethnic background - ages 18-40
- have a score on the Dysmorphic Concern Questionnaire of \<8
- Body dysmorphic disorder: Exclusion
- concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders, as these comorbidities are very common and the sample would otherwise be non-representative...
- lifetime: bipolar disorder or psychotic disorder.
- psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken...
- current cognitive-behavioral therapy Exclusion: Subclinical body dysmorphic disorder: Exclusion
- meet full DSM-5 criteria for Body Dysmorphic Disorder
- current Axis I disorders including substance use disorders
- lifetime: bipolar disorder or psychotic disorder
- psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken...
- current cognitive-behavioral therapy Exclusion Criteria: Healthy Controls: Exclusion
- Any current Axis I disorder
- lifetime: bipolar disorder or psychotic disorder
- Psychiatric medication Exclusion Criteria: All participants: Exclusion
- Neurological disorder
- Pregnancy
- Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders - Current risk of suicide with a plan and intent
- Ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates)
- Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart (vision will be tested with corrective lenses if participant uses them).
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.