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New treatment option for Autonomic Failure
Official title [18F]F-DOPA Imaging in Patients With Autonomic Failure
ClinicalTrials.gov ID: NCT04246437
What this study is testing
What is [18F]FDOPA?
[18F]FDOPA is an investigational medicine, given as an injectable medicine, being studied as a potential treatment for autonomic failure.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-synuclein inclusions (Lewy Bodies) and the pattern of progressive neuronal death (e.g.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients with a diagnosis if pure autonomic failure
- Patients with autonomic failure and possible PD, MSA, or DLB
- Healthy adults aged 18 and above
- Clinical exam confirming clinical designation
You likely can't join if
- people who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators...
- people who have any type of ferromagnetic bioimplant that could potentially be displaced.
- people who have cerebral aneurysm clips.
- people who may have shrapnel imbedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or...
- people who are pregnant, because the effects of high field MRI on fetuses are not yet known.
- Minors (younger than 18 years) Also excluded are people incapable of giving informed written consent:
See the full eligibility criteria
- Patients with a diagnosis if pure autonomic failure
- Patients with autonomic failure and possible PD, MSA, or DLB
- Healthy adults aged 18 and above
- Clinical exam confirming clinical designation
- people who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.), because such...
- people who have any type of ferromagnetic bioimplant that could potentially be displaced.
- people who have cerebral aneurysm clips.
- people who may have shrapnel imbedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
- people who are pregnant, because the effects of high field MRI on fetuses are not yet known.
- Minors (younger than 18 years) Also excluded are people incapable of giving informed written consent:
- people who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher.
- people who have limited mental ability to give informed consent, mentally retarded, altered mental status, mental disability, confusion, or psychiatric disorders.
- Prisoners
The study team makes the final eligibility decision.
Where it's taking place
- Nashville, Tennessee, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nashville, Tennessee, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.