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Official title Physiological Effects of ANGPTL3 Variants in Humans
ClinicalTrials.gov ID: NCT04234724
What this study is testing
- What it's testing
- To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- people aged 18 or older meeting at least one of the following criteria
- Carrying genetic variants in the gene encoding for ANGPTL3,
- Unaffected controls matched for age, race, gender,
- Willing to follow study procedures
- Able to provide inform consent
You likely can't join if
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation...
- Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or...
- Women that are pregnant or nursing
- History of liver disease or abnormal liver function tests (\>2x upper limit of normal)
- History of kidney disease or chronic renal insufficiency (eGFR \<60 mL/min/1.73 m2)
- Uncontrolled hypertension (\>160/100 mmHg)
See the full eligibility criteria
- people aged 18 or older meeting at least one of the following criteria
- Carrying genetic variants in the gene encoding for ANGPTL3,
- Unaffected controls matched for age, race, gender,
- Willing to follow study procedures
- Able to provide inform consent
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Women that are pregnant or nursing
- History of liver disease or abnormal liver function tests (\>2x upper limit of normal)
- History of kidney disease or chronic renal insufficiency (eGFR \<60 mL/min/1.73 m2)
- Uncontrolled hypertension (\>160/100 mmHg)
- Uncontrolled diabetes
- Anemia (hemoglobin \<11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
- History of any organ transplant
- History of alcohol or drug abuse
- Participation in clinical trials assessing the how well it works and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of...
- Inability to comply to study procedures
The study team makes the final eligibility decision.
Where it's taking place
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.