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New treatment option for IBS - Irritable Bowel Syndrome
Official title Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome
ClinicalTrials.gov ID: NCT04217733
What this study is testing
What is pentoxyifylline?
pentoxyifylline is an investigational medicine, given as an once-daily, being studied as a potential treatment for ibs - irritable bowel syndrome.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years,
- Man and Women, Negative pregnancy test and effective contraception,
- IBS defined by the Rome criteria IV
- During the previous seven days the inclusion visit, average numeric rating scale (NRS) pain ≥ 4.
- IBS Treatment stable for 1 month
You likely can't join if
- Breastfeeding
- Diabetic patients
- Significant liver function abnormalities (transaminases\> 3N, cholestasis) and moderate renal disease (MDRD \<60 ml / min)
- Addiction to alcohol and / or drugs,
- Antiepileptic drugs taken (epilepsy or chronic pain)
- Chronic pain of greater intensity than that related to IBS,
See the full eligibility criteria
- Age ≥ 18 years,
- Man and Women, Negative pregnancy test and effective contraception,
- IBS defined by the Rome criteria IV
- During the previous seven days the inclusion visit, average numeric rating scale (NRS) pain ≥ 4.
- IBS Treatment stable for 1 month
- Breastfeeding
- Diabetic patients
- Significant liver function abnormalities (transaminases\> 3N, cholestasis) and moderate renal disease (MDRD \<60 ml / min)
- Addiction to alcohol and / or drugs,
- Antiepileptic drugs taken (epilepsy or chronic pain)
- Chronic pain of greater intensity than that related to IBS,
- Known Allergyto succinimides (ethosuximide, methsuximide, phensuximide) and pentoxifylline.
- History or current severe depression (hospitalization, long-term antidepressant treatment)
- Psychotic disorders,
The study team makes the final eligibility decision.
Where it's taking place
- Tanta, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tanta, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.