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New treatment option for IVF Outcome
Official title Trigger Timing in Ovarian Stimulations
ClinicalTrials.gov ID: NCT04163133
What this study is testing
- What it's testing
- The use of antagonist ovulation stimulation program is increasing year by year, because of its convenience, flexibility, and prevention effect of ovarian hyperstimulation syndrome. However, many researchers and clinicians believe that the clinical outcomes of antagonist regimens are worse than those of classical long-term regimens.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 42, women only
You may be able to join if
- Age: ≥18 and \<42 years old
- AFC: ≥5 and \<20
- AMH: ≥1.1 ng/mL and \<2.5 ng/mL
- BMI: ≥18.5 Kg/m2 and \<29 Kg/m
- First or second ART cycle
You likely can't join if
- Women with contraindication for IVF or ICSI, such as poorly controlled type 1 or type 2 diabetes mellitus; undiagnosed liver disease or dysfunction...
- Previous history of poor ovarian response (\<4 oocytes retrieved) with a maximal dose of OS (≥300 IU/day) or OHSS, regardless of gonadotropin dose
- Known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting the endometrial cavity, Asherman's syndrome, thrombophilia or...
- Repeated miscarriages (\>2 previous biochemical pregnancies or \>2 spontaneous miscarriages)
- Recurrent implantation failure (\>3 failed cycles with good quality embryos)
- PCOS
See the full eligibility criteria
- Age: ≥18 and \<42 years old
- AFC: ≥5 and \<20
- AMH: ≥1.1 ng/mL and \<2.5 ng/mL
- BMI: ≥18.5 Kg/m2 and \<29 Kg/m
- First or second ART cycle
- Regular menstrual cycles (between 22 and 35 days)
- Two ovaries present
- Planned for single or double day 3 transfer
- Infertile couples scheduled for their first IVF/ICSI cycle with fixed antagonist protocol.
- Informed consent obtained.
- Women with contraindication for IVF or ICSI, such as poorly controlled type 1 or type 2 diabetes mellitus; undiagnosed liver disease or dysfunction (based on serum liver enzyme test results); renal disease or abnormal...
- Previous history of poor ovarian response (\<4 oocytes retrieved) with a maximal dose of OS (≥300 IU/day) or OHSS, regardless of gonadotropin dose
- Known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting the endometrial cavity, Asherman's syndrome, thrombophilia or endometrial tuberculosis)
- Repeated miscarriages (\>2 previous biochemical pregnancies or \>2 spontaneous miscarriages)
- Recurrent implantation failure (\>3 failed cycles with good quality embryos)
- PCOS
- Untreated thyroid disfunction
- Administration of exogenous E2, P4 or gonadotropins in the preceding menstrual cycle
- Active female smoking
- Ongoing pregnancy
- Women who have previously enrolled in the trial
- Those unable to comprehend the investigational nature of the proposed study
- either male partner or female partner has to receive donor sperm or donor eggs.
- Either male partner or female partner has to receive PGD and PGS.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, Beijing Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 42 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, Beijing Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.