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Tests treatment safety and results for Solid Tumor
Official title Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors
ClinicalTrials.gov ID: NCT04064359
What this study is testing
What is OBT076, a CD205-directed antibody-drug conjugate?
OBT076, a CD205-directed antibody-drug conjugate is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for solid tumor.
Also referred to as MEN1309.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate OBT076, which is a drug that combines an antibody with an anti-cancer drug. This class of drugs are called Antibody-Drug Conjugates (ADC).
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Subject is ≥ 18 years of age (at the time of signing the ICF) with non-curative recurrent and/or metastatic solid tumors for which a standard therapy...
- Subject has histologically and/or cytologically confirmed solid tumors.
- Subject with Breast cancer:
- Subject with hormone-receptor positive (as per local laboratory) recurrent locally advanced or metastatic breast cancer, regardless of HER2 status...
- Subject with recurrent locally advanced or metastatic non-curative HER2 negative breast cancer (based on most recently analyzed biopsy), HER2 status...
You likely can't join if
- Subject has received any chemotherapy within 28 days prior to Cycle 1 Day 1.
- Subject has received any other systemic anticancer therapy within 28 days or 5 half-lives of Cycle 1 Day 1.
- Subject has symptomatic visceral crisis requiring chemotherapy per Investigator judgment for non TNBC.
- Subject with colorectal cancer and pancreatic cancer are not eligible for the study.
- Subject with peritoneal involvement, i.e., peritoneal carcinomatosis, are not eligible for the study.
- Subject has not recovered from the acute toxic effects (CTCAE grade ≤ 1) of prior anticancer therapy, radiation, or major surgery/significant trauma...
See the full eligibility criteria
Who can join
- Subject is ≥ 18 years of age (at the time of signing the ICF) with non-curative recurrent and/or metastatic solid tumors for which a standard therapy is not available or is no longer effective.
- Subject has histologically and/or cytologically confirmed solid tumors.
- Subject with Breast cancer:
- Subject with hormone-receptor positive (as per local laboratory) recurrent locally advanced or metastatic breast cancer, regardless of HER2 status, must have received at least two prior lines of endocrine therapy in the...
- Subject with recurrent locally advanced or metastatic non-curative HER2 negative breast cancer (based on most recently analyzed biopsy), HER2 status is defined as per ASCO-CAP guidelines as negative, if in situ...
- Subject with triple negative breast cancer are eligible after at least one prior line of cytotoxic chemotherapy in the metastatic setting.
- Subject with prior adjuvant or neoadjuvant chemotherapy allowed.
- Subject has received a maximum of two prior lines of cytotoxic chemotherapy in the metastatic setting. Subject who received three up to five prior lines of cytotoxic chemotherapy in the metastatic setting are eligible...
- Subject has tumor that is positive for CD205 antigen by IHC staining
- Subject has an ECOG performance status of 0-1.
- Subject has radiological documented measurable disease (i.e., at least 1 measurable lesion as per RECIST Version 1.1).
- Subject has adequate organ function
- Subject has adequate bone marrow function
- Subject understands and voluntarily signs an ICD prior to any study-related assessments/procedures are conducted.
- Subject is able to adhere to the study visit schedule and other protocol requirements.
- Subject who is a female of childbearing potential (defined as a sexually mature women, has not undergone hysterectomy (the surgical removal of the uterus) or bilateral oophorectomy (the surgical removal of both ovaries)...
- Have a negative pregnancy test within 1 week before first dose of study drug.
- Use highly effective method(s) of birth control consistently and correctly during the study and for at least 4 months after the last dose of study drug.
- Agree to not donate eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for at least 4 months after the last dose of study.
- Agree to no plan to breastfeed and no plan to become pregnant during the study and for at least 4 months after the last dose of study drug.
- Subject who is a sexually active male must agree to use a condom, not to donate sperm and have no plans to father a child during the study and for at least 4 months after the last dose of study drug.
What rules you out
- Subject has received any chemotherapy within 28 days prior to Cycle 1 Day 1.
- Subject has received any other systemic anticancer therapy within 28 days or 5 half-lives of Cycle 1 Day 1.
- Subject has symptomatic visceral crisis requiring chemotherapy per Investigator judgment for non TNBC.
- Subject with colorectal cancer and pancreatic cancer are not eligible for the study.
- Subject with peritoneal involvement, i.e., peritoneal carcinomatosis, are not eligible for the study.
- Subject has not recovered from the acute toxic effects (CTCAE grade ≤ 1) of prior anticancer therapy, radiation, or major surgery/significant trauma (except alopecia or other toxicities not considered a safety risk for...
- Subject has had major surgery within 14 days prior to starting study treatment or has not recovered from major side effects.
- Subject has had radiotherapy ≤ 4 weeks prior to starting study drug.
- Subject has a history of, or current symptomatic brain metastasis.
- Subject has any other malignancy within 5 years prior to randomization
- Subject has a known or suspected hypersensitivity or other contraindication to any excipients used in the manufacture of OBT076.
- Subject has significant medical condition, laboratory abnormality, or psychiatric illness that would, in the Investigator's judgment, contraindicate patient participation in the study (e.g., history of thromboembolic...
- Subject has severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine \<7 days before Cycle 1 Day 1
- Subject has any condition that confounds the ability to interpret data from the study.
- Subject is lactating or breastfeeding.
- Subject has a past medical history of or ongoing clinically relevant interstitial lung disease, drug-induced pneumonitis or severe/very severe COPD.
- Subject has active or chronic corneal disorder or Sjogren's syndrome.
- Subject has any ongoing skin disorders not controlled by specific treatment.
- Subject has significant active cardiac disease within the previous 6 months including unstable angina or angina requiring surgical or medical intervention, significant cardiac arrhythmia, or NYHA class 3 or 4 congestive...
- Subject has a known history or current diagnosis of HIV infection, unless on triple antiviral treatment with undetectable viral load.
- Subject who is female of childbearing potential
- Subject who is unable or unwilling to take folic acid or vitamin B12 supplementation.
- Subject with a history of allogeneic organ transplant.
- Subject with grade 3 or 4 immune-related adverse reactions during any prior line of checkpoint inhibitor containing therapy. Patients with immune-related thyroiditis controlled with substitution, or prior asymptomatic...
- Subject with active autoimmune disease or history of autoimmune disease that required systemic treatment within 3 years of the start of study treatment. Additional inclusion criteria specific for Part E: 1\. Patients...
- The presence of any contraindication to gemcitabine as per applicable Summary of Product Characteristics/label.
- Patients with a condition requiring systemic treatment with either corticosteroids (\>10 mg daily prednisone equivalent) within the 14 days prior to the first dose of study treatment or another immunosuppressive...
- Patients with urothelial cancer and any history or current CNS metastasis.
- Patients who were hospitalized during screening for infectious complications or required IV antibiotics in the 14 days prior to Cycle 1 Day 1.
- Patients who presented in the 14 days prior to or on Cycle 1 Day 1 with one or more of the following:
- ANC of \<1.5 x 109 cells/L
- Platelets of \< 100 x 109 cells/L
- Hemoglobin of \< 9 g/dL
- Patients who received G-CSF in the 14 days prior to Cycle 1 Day 1
- Patients who had febrile neutropenia during the previous line of therapy or during the last line of therapy containing cytotoxic chemotherapy.
- Patients who are primary refractory to anti-PD-(L)1 directed therapy.
- Patients with NSCLC and more than 2 prior lines of systemic anti-cancer therapy in the locally-advanced/metastatic disease setting; and who received more than one prior line of cytotoxic chemotherapy in the...
- Patients with urothelial cancer who received more than 3 prior lines of systemic anti cancer therapy in locally-advanced/metastatic disease setting. Prior neoadjuvant or adjuvanttherapy is not counted.
The study team makes the final eligibility decision.
Where it's taking place
- Phoenix, Arizona, United States
- Los Angeles, California, United States
- Santa Monica, California, United States
- Tampa, Florida, United States
- Iowa City, Iowa, United States
- Edgewood, Kentucky, United States
- Jackson, Mississippi, United States
- Santa Fe, New Mexico, United States
- New York, New York, United States
- Pittsburgh, Pennsylvania, United States
- Brussels, Belgium
- Kortrijk, Belgium
- Marseille, France
- Paris, France
- Rennes, France
- Strasbourg, France
- Villejuif, France
- Chaïdári, Athens, Greece
- Athens, Greece
- Heraklion, Greece
+ 4 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Phoenix, Arizona, United States; Los Angeles, California, United States; Santa Monica, California, United States; Tampa, Florida, United States; Iowa City, Iowa, United States; Edgewood, Kentucky, United States and 18 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.