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New treatment option for Huntington Disease
Official title Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
ClinicalTrials.gov ID: NCT04012411
What this study is testing
What is Blood sample?
Blood sample is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for huntington disease.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have been evoked, including an alteration of the signaling pathway of the Brain Derived Neurotrophic Factor (BDNF), a neurotrophic factor involved in the survival of neurons (striatal and hippocampal) and synaptic plasticity.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- General
- age ≥ 18 years-old
- national health insurance cover
- Patients
- genetically confirmed Huntington's disease diagnosis (≥ 35 CAG repeat in HTT gene exon 1)
You likely can't join if
- General exclusion criteria:
- protected by law
- Patients exclusion criteria:
- Huntington's disease stage too Evolved that may interfere with cognitive evaluations or MRI
- contraindications to brain MRI
- only for patients "with LP": contraindications to LP
See the full eligibility criteria
- General
- age ≥ 18 years-old
- national health insurance cover
- Patients
- genetically confirmed Huntington's disease diagnosis (≥ 35 CAG repeat in HTT gene exon 1)
- written informed consent
- only for patients "with lumbar puncture (LP)": patient agreement for LP
- Control
- anterior LP for medical reason with consent for biobank "Neuro" with following samples present in this biobank : 2 mL blood + 0.5 mL plasma + 0.5 mL cerebrospinal fluid
- information and non-opposition for the finality of this biobank
- paired by age with a patient (+/- 5 years difference)
- General exclusion criteria:
- protected by law
- Patients exclusion criteria:
- Huntington's disease stage too Evolved that may interfere with cognitive evaluations or MRI
- contraindications to brain MRI
- only for patients "with LP": contraindications to LP
- incapacity to give informed consent
- Control exclusion criteria:
- neurodegenerative of inflammatory central nervous system pathology
The study team makes the final eligibility decision.
Where it's taking place
- Montpellier, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Montpellier, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.