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New treatment option for ARDS
Official title Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
ClinicalTrials.gov ID: NCT03963622
What this study is testing
- What it's testing
- This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 y
- Moderate or severe ARDS (PaO2/FiO2 ≤ 200 mmHg) within 48 h of meeting Berlin ARDS criteria (Patients who were eligible at the time of screening and...
You likely can't join if
- Received continuous mechanical ventilation \> 7 days
- Known or clinically suspected elevated intracranial pressure (\>18mmHg) necessitating strict control of PaCO2
- Known pregnancy
- Broncho-pleural fistula
- Severe liver disease (Child-Pugh Score ≥ 10)
- BMI \>40kg/m2
See the full eligibility criteria
- Age ≥ 18 y
- Moderate or severe ARDS (PaO2/FiO2 ≤ 200 mmHg) within 48 h of meeting Berlin ARDS criteria (Patients who were eligible at the time of screening and whose PaO2/FiO2 became \> 200 mm Hg under prone positioning when...
- Received continuous mechanical ventilation \> 7 days
- Known or clinically suspected elevated intracranial pressure (\>18mmHg) necessitating strict control of PaCO2
- Known pregnancy
- Broncho-pleural fistula
- Severe liver disease (Child-Pugh Score ≥ 10)
- BMI \>40kg/m2
- Anticipating withdrawal of life support and/or shift to palliation as the goal of care
- Patient is receiving ECMO at time of randomization
The study team makes the final eligibility decision.
Where it's taking place
- New York, New York, United States
- Buenos Aires, Argentina
- San Martin, Argentina
- Toronto, Canada
- Santiago, Chile
- Amiens, France
- Angers, France
- Argenteuil, France
- Beauvais, France
- Bordeaux, France
- Brest, France
- Cholet, France
- Créteil, France
- Grenoble, France
- Lille, France
- Mulhouse, France
- Nice, France
- Paris, France
- Poitiers, France
- Vannes, France
+ 6 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include New York, New York, United States; Buenos Aires, Argentina; San Martin, Argentina; Toronto, Canada; Santiago, Chile; Amiens, France and 20 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.