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New treatment option for Hepatitis B
Official title Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
ClinicalTrials.gov ID: NCT03920618
What this study is testing
What is Entecavir?
Entecavir is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for hepatitis b.
Also referred to as Baraclude.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 to 65
You may be able to join if
- Positive hepatitis b surface antigen or hepatitis b virus DNA \> 0.5 year;
- Age from 12 to 65 years old;
- Serum total bilirubin level \> 10 times upper limit of normal;
- Prothrombin time activity \ 1.5；
- Do not receive nucleotide/nucleoside analogues treatment in the past half year.
You likely can't join if
- Other active liver diseases;
- Hepatocellular carcinoma or other malignancy;
- Pregnancy or lactation;
- Human immunodeficiency virus infection or congenital immune deficiency diseases;
- Severe diabetes, autoimmune diseases;
- Other important organ dysfunctions;
See the full eligibility criteria
- Positive hepatitis b surface antigen or hepatitis b virus DNA \> 0.5 year;
- Age from 12 to 65 years old;
- Serum total bilirubin level \> 10 times upper limit of normal;
- Prothrombin time activity \ 1.5；
- Do not receive nucleotide/nucleoside analogues treatment in the past half year.
- Other active liver diseases;
- Hepatocellular carcinoma or other malignancy;
- Pregnancy or lactation;
- Human immunodeficiency virus infection or congenital immune deficiency diseases;
- Severe diabetes, autoimmune diseases;
- Other important organ dysfunctions;
- Using glucocorticoid;
- Patients can not follow-up;
- Investigator considering inappropriate.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.