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New treatment option for Glaucoma, Open-Angle
Official title Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
ClinicalTrials.gov ID: NCT03870230
What this study is testing
- What it's testing
- Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects. The main risk factor for glaucoma is elevated intraocular pressure (IOP).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients with primary open angle glaucoma
- Diagnosis of manifest primary open angle glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- Untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- Mean deviation in the visual field test is less than or equal 10dB (for one group) OR more than 10dB (for the other group) Patients with normal...
You likely can't join if
- History of a severe medical condition as judged by the clinical investigator
- Abuse of alcoholic beverages
- Smoker
- Participation in a clinical trial in the 3 weeks preceding the study
- Exfoliation glaucoma, pigmentary glaucoma, history of acute angle closure
- Intraocular surgery within the last 6 months
See the full eligibility criteria
- Patients with primary open angle glaucoma
- Diagnosis of manifest primary open angle glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- Untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- Mean deviation in the visual field test is less than or equal 10dB (for one group) OR more than 10dB (for the other group) Patients with normal tension glaucoma
- Diagnosis of manifest normal tension glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- No evidence of untreated IOP \> 20 mmHg in the medical history
- Mean deviation in the visual field is less than or equal 10dB (for one group) OR more than 10dB (for the other group) Patients with ocular hypertension
- Normal ophthalmic findings except presence of ocular hypertension defined as untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test Healthy control people
- Normal ophthalmic findings
- IOP \< 20 mmHg on least three measurements
- No evidence of increased IOP in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test
- History of a severe medical condition as judged by the clinical investigator
- Abuse of alcoholic beverages
- Smoker
- Participation in a clinical trial in the 3 weeks preceding the study
- Exfoliation glaucoma, pigmentary glaucoma, history of acute angle closure
- Intraocular surgery within the last 6 months
- Ocular inflammation or infection within the last 3 months
- History of epilepsia
- Diabetes mellitus
- Untreated hypertension with systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 95 mmHg
- Pregnancy
- Planned pregnancy or lactating
The study team makes the final eligibility decision.
Where it's taking place
- Vienna, Austria
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Vienna, Austria. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.