Recruiting NA Sarcoidosis With Myocarditis

New treatment option for Sarcoidosis With Myocarditis

Official title Cell Free DNA in Cardiac Sarcoidosis

ClinicalTrials.gov ID: NCT03858777

What this study is testing

What it's testing: Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality.

A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.

Who can take part

Ages 18 and older. Healthy volunteers may be eligible.

You may be able to join if

Sarcoidosis patients without evidence of active myocarditis:
Inclusion:
Diagnosis of sarcoidosis based on the ATS/ERS criteria.
Normal 12 lead ECG within the past one year.
Non-smoker.

See the full eligibility criteria

Who can join

Sarcoidosis patients without evidence of active myocarditis:
Inclusion:
Diagnosis of sarcoidosis based on the ATS/ERS criteria.
Normal 12 lead ECG within the past one year.
Non-smoker.
No immunosuppressive therapy for at least one year.
Exclusion:
Known cardiac disease.
Active smoker.
On immunosuppressive therapy.
Sarcoidosis patients with evidence of active myocarditis:
Inclusion:
Diagnosis of sarcoidosis based on the ATS/ERS criteria.
Evidence of active myocarditis based on recent cMRI or cFDG-PET.
Non-smoker.
Exclusion:
Known cardiac disease other than sarcoidosis.
Active smoker.
On immunosuppressive therapy.
Acute ST elevation myocardial infarction (STEMI):
Inclusion:
Diagnosis STEMI based on 1mm ST elevation in 2 or more contiguous leads.
Symptom onset within 12 hours.
Undergoing cardiac intervention for acute coronary syndrome.
Able to consent for blood draw.
Exclusion:
Active smoker.
Hemodynamically unstable.
Healthy controls:
Inclusion:
No known cardiac disease.
No known cardiovascular risk factors: hypertension, diabetes.
Non-smoker.

The study team makes the final eligibility decision.

Where it's taking place

Iowa City, Iowa, United States

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.

Where is this trial taking place?

Study sites include Iowa City, Iowa, United States. Enter your location above to see the nearest site and check your eligibility.

Explore other conditions

Obesity Type 2 diabetes Type 1 diabetes Prediabetes Weight loss Metabolic syndrome High cholesterol High triglycerides High blood pressure PCOS Hypothyroidism Thyroid disease Gout Fatty liver disease (NAFLD/NASH)Heart failure Coronary artery disease

BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.