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New treatment option for Hypertension
Official title Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
ClinicalTrials.gov ID: NCT03821623
What this study is testing
What is Nicotinamide riboside?
Nicotinamide riboside is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for hypertension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased CVD risk.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older. Healthy volunteers may be eligible.
You may be able to join if
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Systolic blood pressure between 120 and 159 mmHg
- Body mass index \<40 kg/m2
- Weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable throughout the study
You likely can't join if
- Systolic blood pressure \ /= 160 mmHg
- Currently taking antihypertensive medications
- Other chronic medical condition (e.g., diabetes, chronic kidney disease, cancer)
- Current smoker
- Alcohol dependence or abuse
- Uncontrolled thyroid disease or change in thyroid medication within previous 3 months
See the full eligibility criteria
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Systolic blood pressure between 120 and 159 mmHg
- Body mass index \<40 kg/m2
- Weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable throughout the study
- Absence of other clinical disease as determined by medical history, physical examination, blood chemistries, ankle-brachial index, and 12-lead ECG at rest and during graded treadmill exercise
- Ankle-brachial index \>0.7
- Total cholesterol \<240 mg/dL
- Fasting plasma glucose \<126 mg/dL
- Normal 12-lead ECG at rest and during graded treadmill exercise to fatigue
- Systolic blood pressure \ /= 160 mmHg
- Currently taking antihypertensive medications
- Other chronic medical condition (e.g., diabetes, chronic kidney disease, cancer)
- Current smoker
- Alcohol dependence or abuse
- Uncontrolled thyroid disease or change in thyroid medication within previous 3 months
- Abnormal blood pressure response to exercise (drop in SBP below resting pressure or SBP \>160 mmHg or DBP \>115 mmHg)
- Regular vigorous aerobic/endurance exercise (\>4 bouts/weeks, \>30 min/bout at a workload \>6 METS)
The study team makes the final eligibility decision.
Where it's taking place
- Boulder, Colorado, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boulder, Colorado, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.