BridgeMD
New treatment option for Non-Alcoholic Fatty Liver Disease
Official title Cold-induced Brown Fat Activation and Hepatic Steatosis
ClinicalTrials.gov ID: NCT03811236
What this study is testing
- What it's testing
- In the recent years, research on brown adipose tissue (BAT) revealed that larger amounts as well as higher activity thereof are associated with a favourable metabolic phenotype. Longitudinal studies which applied recurrent cooling sessions demonstrated a high plasticity of BAT which significantly increased in size and activity during these studies.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50
You may be able to join if
- body mass index 28 - 40 kg/m\^2
- hepatic lipid content \> 10 %
You likely can't join if
- endocrine disease, except treated hypo-/hyperthyroidism and hypertriglyceridemia (\<500 mg/dl) and untreated type II diabetes mellitus (fasting...
- use of beta-blockers, alpha-blockers and rilmenidine
- chronic kidney disease
- inflammatory bowel disease
- active malignant disease
- autoimmune disease
See the full eligibility criteria
- body mass index 28 - 40 kg/m\^2
- hepatic lipid content \> 10 %
- endocrine disease, except treated hypo-/hyperthyroidism and hypertriglyceridemia (\<500 mg/dl) and untreated type II diabetes mellitus (fasting glucose \< 140 mg/dl)
- use of beta-blockers, alpha-blockers and rilmenidine
- chronic kidney disease
- inflammatory bowel disease
- active malignant disease
- autoimmune disease
- chronic alcohol abuse or alcohol consumption greater than 30g/d for men or 20 g/d for women
- transferrin saturation \> 40%
- serum alpha-1 antitrypsin \< 90 mg/dl
- serum ceruloplasmin \< 20 mg/dl
- positive serology for autoimmune hepatitis
- positive hepatitis serology
- liver cirrhosis
- portal hypertension
- pregnancy
- contraindications for magnetic resonance imaging
The study team makes the final eligibility decision.
Where it's taking place
- Vienna, Austria
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Vienna, Austria. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.