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New treatment option for Exposure to Pollution
Official title Diesel Exhaust Induces Glucocorticoid Resistance
ClinicalTrials.gov ID: NCT03615742
What this study is testing
What is Budesonide?
Budesonide is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for exposure to pollution.
Also referred to as Pulmicort.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 49
You may be able to join if
- Aged 19-49
- Have physician-diagnosed asthma confirmed by the study physician examination, spirometry, methacholine challenge provocative concentration causing a...
You likely can't join if
- Smoking of any kind (0.5 pack-years ever, or any current) or use of vape/vaporizing devices
- Regular anti-histamine, NSAID, corticosteroid or other controller medication use
- Pregnancy or breastfeeding
- Methacholine PC20 \>16
- Relevant cardiac condition or arrhythmia
- Body mass index of \>35
See the full eligibility criteria
- Aged 19-49
- Have physician-diagnosed asthma confirmed by the study physician examination, spirometry, methacholine challenge provocative concentration causing a 20% fall (PC20) of \<16 mg/mL, and questionnaires during a screening...
- Smoking of any kind (0.5 pack-years ever, or any current) or use of vape/vaporizing devices
- Regular anti-histamine, NSAID, corticosteroid or other controller medication use
- Pregnancy or breastfeeding
- Methacholine PC20 \>16
- Relevant cardiac condition or arrhythmia
- Body mass index of \>35
- Currently participating in another study that may interfere with this study
- Use of either inhaled or oral corticosteroids in preceding 6 months
- Substantial comorbidities on study physician's examination or other concerns
- Surgery scheduled before anticipated study completion
The study team makes the final eligibility decision.
Where it's taking place
- Vancouver, British Columbia, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years to 49 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Vancouver, British Columbia, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.