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Official title Study of Coronary Calcium Score as a Marker of Post-radiation Vascular Dysplasia in Adults Treated During Childhood for Cancer With Mediastinal Irradiation
ClinicalTrials.gov ID: NCT03604627
What this study is testing
- What it's testing
- To measure coronary calcium score in adults treated during childhood or adolescence for irradiation cancer in the heart and / or anthracycline area and compare them to determine whether irradiation of the heart area is associated with increased calcium score after adjustment for other cardiovascular risk factors (age, sex, smoking, dyslipidemia, obesity, diabetes, high blood pressure and renal failure).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients 18 years of age or older,
- Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
- Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate) and / or anthracycline (cumulative dose of doxorubicin equivalent ≥300mg/m\^²),
- In complete remission of their pediatric cancer for at least 10 years,
- Patient affiliated to a social security scheme or beneficiary of such a scheme,
You likely can't join if
- Perspective less than 10 years,
- Persons deprived of liberty or guardianship (including trusteeship),
- Impossibility of submitting to the medical follow-up of the test for geographical, social or psychological reasons,
- Pregnant women. Inclusion criteria for extension cohort:
- Patients 30 years of age or older,
- Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
See the full eligibility criteria
- Patients 18 years of age or older,
- Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
- Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate) and / or anthracycline (cumulative dose of doxorubicin equivalent ≥300mg/m\^²),
- In complete remission of their pediatric cancer for at least 10 years,
- Patient affiliated to a social security scheme or beneficiary of such a scheme,
- Patient Information and Signed Informed Consent.
- Perspective less than 10 years,
- Persons deprived of liberty or guardianship (including trusteeship),
- Impossibility of submitting to the medical follow-up of the test for geographical, social or psychological reasons,
- Pregnant women. Inclusion criteria for extension cohort:
- Patients 30 years of age or older,
- Treated for cancer during childhood, adolescence or young adulthood (≤25 years),
- Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate),
- In complete remission of their pediatric cancer for at least 10 years,
- Patient affiliated to a social security scheme or beneficiary of such a scheme,
- Patient Information and Signed Informed Consent. Exclusion criteria for extension cohort:
- Persons deprived of liberty or guardianship (including trusteeship),
- Impossibility of submitting to the medical follow-up of the test for geographical, social or psychological reasons,
- Pregnant women.
The study team makes the final eligibility decision.
Where it's taking place
- Villejuif, Val De Marne, France
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Villejuif, Val De Marne, France; Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.