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New treatment option for Postoperative Pain
Official title Dexmedetomidine and Ketamine in VATS Surgery
ClinicalTrials.gov ID: NCT03596424
What this study is testing
What is Ketamine Hydrochloride?
Ketamine Hydrochloride is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for postoperative pain.
Also referred to as ketamine.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery. To reduce this requirement, multimodal analgesia with non opioid medication such as dexmedetomidine and ketamine can be used.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Patients aged 18-80 years old
- American Society of Anesthesiology physical status I-III
- Elective Video-Assisted Thoracic Surgery for pulmonary resection
You likely can't join if
- Patients for which a regional anesthesia technique is planned for postoperative analgesia.
- Patients taking beta-blockers preoperatively.
- Patients with chronic pain taking \>60 mg morphine PO daily (or its equivalent).
- Patients taking pregabalin, gabapentin, amitryptillin, nortryptillin and/or duloxetin.
- Documented allergy to ketamine and/or dexmedetomidine.
- Pregnancy
See the full eligibility criteria
- Patients aged 18-80 years old
- American Society of Anesthesiology physical status I-III
- Elective Video-Assisted Thoracic Surgery for pulmonary resection
- Patients for which a regional anesthesia technique is planned for postoperative analgesia.
- Patients taking beta-blockers preoperatively.
- Patients with chronic pain taking \>60 mg morphine PO daily (or its equivalent).
- Patients taking pregabalin, gabapentin, amitryptillin, nortryptillin and/or duloxetin.
- Documented allergy to ketamine and/or dexmedetomidine.
- Pregnancy
- Inability to give informed consent
- Linguistic barrier.
- Patient refusal
The study team makes the final eligibility decision.
Where it's taking place
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Montreal, Quebec, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.