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New treatment option for Alzheimer Disease
Official title Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
ClinicalTrials.gov ID: NCT03472664
What this study is testing
- What it's testing
- The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment. The data collected will help determine whether diet interventions induce changes in cognitive function, cerebral blood flow, and levels of certain proteins and hormones in body fluids.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 85
You may be able to join if
- Diagnosis of amnestic mild cognitive impairment
- An informant (study partner) able to provide collateral information on the participant
- Stable medical condition (generally 3 months prior to screening visit) at the discretion of study physician
- Stable on medications (generally 4 weeks prior to screening visit) at the discretion of study physician
- Able to complete baseline assessments
You likely can't join if
- Diagnosis of neurodegenerative illness (except for MCI);
- History of a clinically significant stroke
- Current evidence or history in past year of focal brain lesion, head injury with loss of consciousness or DSM-IV criteria for any major psychiatric...
- Sensory impairment (i.e.: visual or auditory) that would preclude the participant from participating in the protocol
- Diabetes that requires current use of diabetes medications
- Clinically significant elevations in liver function tests
See the full eligibility criteria
- Diagnosis of amnestic mild cognitive impairment
- An informant (study partner) able to provide collateral information on the participant
- Stable medical condition (generally 3 months prior to screening visit) at the discretion of study physician
- Stable on medications (generally 4 weeks prior to screening visit) at the discretion of study physician
- Able to complete baseline assessments
- Diagnosis of neurodegenerative illness (except for MCI);
- History of a clinically significant stroke
- Current evidence or history in past year of focal brain lesion, head injury with loss of consciousness or DSM-IV criteria for any major psychiatric disorder including psychosis, major depression, bipolar disorder...
- Sensory impairment (i.e.: visual or auditory) that would preclude the participant from participating in the protocol
- Diabetes that requires current use of diabetes medications
- Clinically significant elevations in liver function tests
- Active neoplastic disease (stable prostate cancer and non-melanoma skin cancer is permissible)
- History of epilepsy or seizure within past year
- Contraindications for MRI (claustrophobia, craniofacial metal implants, pacemakers)
- Significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease
The study team makes the final eligibility decision.
Where it's taking place
- Winston-Salem, North Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Winston-Salem, North Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.