BridgeMD
New treatment option for Normal Physiology
Official title Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
ClinicalTrials.gov ID: NCT03258580
What this study is testing
- What it's testing
- Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symptoms, including pain.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- All Sub-Studies:
- Healthy
- Between 18 and 60 years old
- Fluent in English
- Able to provide written informed consent
You likely can't join if
- All Sub-Studies:
- Unable to comply with study procedures
- Has a major-medical condition or medical history that in a clinician's assessment could affect ability to comply with study procedures, including...
- Has a current mood disorder, anxiety disorder, or substance use disorder, or has a history of psychosis, hospitalization for a mental health...
- NIH staff member who is a subordinate/relative/co-worker of any investigator on the protocol
- Prior completion of a different sub-study within this protocol.
See the full eligibility criteria
- All Sub-Studies:
- Healthy
- Between 18 and 60 years old
- Fluent in English
- Able to provide written informed consent
- All Sub-Studies:
- Unable to comply with study procedures
- Has a major-medical condition or medical history that in a clinician's assessment could affect ability to comply with study procedures, including neurological conditions (including stroke, blindness or deafness, or a...
- Has a current mood disorder, anxiety disorder, or substance use disorder, or has a history of psychosis, hospitalization for a mental health condition, or recurrent psychiatric episodes.
- NIH staff member who is a subordinate/relative/co-worker of any investigator on the protocol
- Prior completion of a different sub-study within this protocol.
- Is born outside of the states or territories of the United States of America
- Does not currently reside in a state or territory of the United States of America Sub-study 1:
- Has a major-medical condition or medical history that in a clinician's assessment could affect heat sensitivity or pain thresholds. This may include cardiovascular, autonomic, or neurological conditions or a chronic...
- Has a medical condition that in a clinician's assessment might affect somatosensation (e.g., Raynaud's disease, peripheral neuropathy, or circulatory disorder)
- Has a current chronic pain condition or has had chronic pain in the past (painful condition lasting more than six months)
- Has a dermatological condition affecting the testing region, such as scars, burns, or recent tattoos that might influence cutaneous sensibility
- Regular use of prescription medication that has a significant effect on pain or heat perception. Excluded medications include central-acting agents such as opiates (morphine, tramadol), antidepressants (amitriptyline...
- Is left handed Sub-study 4, FMRI participants:
- Has a current chronic pain condition or has had chronic pain in the past (painful condition lasting more than six months)
- Is left-handed
- Any FMRI contraindications, including:
- Ferromagnetic metal in the cranial cavity or eye, e.g. aneurysm clip, implanted neural stimulator, cochlear implant, ocular foreign body.
- Implanted cardiac pacemaker or auto-defibrillator.
- Insulin pump.
- Irremovable body piercing.
- Pregnant women (based on urine test completed within 24 hours prior to scan).
- Those with an abnormality on a structural MRI that has functional consequences based on clinician assessment.
The study team makes the final eligibility decision.
Where it's taking place
- Bethesda, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bethesda, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.