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New treatment option for Alzheimer Disease
Official title Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
ClinicalTrials.gov ID: NCT03035851
What this study is testing
- What it's testing
- The estimated annual cost of dementia in Canada is $15 billion, with a projected cumulative economic burden of $800 billion by 2038. Effective prevention of dementia at a population level will need to include lifestyle factors such as promoting higher levels of physical activity.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80
You may be able to join if
- inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors...
- Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous...
- Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective...
- Vascular risk factors for ADRD including the following:
- history of hypertension;
You likely can't join if
- diagnosis of a developmental handicap;
- history of dementia (DSM-V criteria)\ \ ;
- terminal illness (life expectancy \< 1 year)
- not fluent in verbal and written English;
- history of stroke;
- currently participating in another trial;
See the full eligibility criteria
- inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors (see below) for ADRD;
- Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous exercise;
- Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective memory complaints in healthy elderly people, in patients with mild...
- Vascular risk factors for ADRD including the following:
- history of hypertension;
- diabetes mellitus;
- obesity (body mass index (BMI) \<40 kg/m2)
- elevated cholesterol;
- currently smoking;
- past history of coronary artery disease without recent (\<5 years) symptoms. Participants must provide a completed PAR-Q+ form (www.csep.ca), the standard method of obtaining physician approval for participation in an...
- diagnosis of a developmental handicap;
- history of dementia (DSM-V criteria)\ \ ;
- terminal illness (life expectancy \< 1 year)
- not fluent in verbal and written English;
- history of stroke;
- currently participating in another trial;
- comorbid medical or neurological illnesses (e.g., multiple sclerosis) that would confound cognitive assessments or make trial completion unlikely (in the site investigator's opinion);
- contraindication for the intervention;
- contraindication for an MRI exam.
- \ \ Existing or suspected dementia will be identified by medical history, cognitive impairment on the Telephone Interview for Cognitive Status (TICS-modified; score≤ 20), or impaired Instrumental Activities of Daily...
The study team makes the final eligibility decision.
Where it's taking place
- Calgary, Alberta, Canada
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Calgary, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.