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Compares treatment options for Exacerbation Copd
Official title High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov ID: NCT03033251
What this study is testing
- What it's testing
- Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide. The disease is marked by multiples episode of worsening, termed exacerbations necessitating frequent hospitalizations.
- This is a blinded study.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by
- Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);
- Respiratory rate≥20 breaths/min;
- Activation of accessory respiratory muscles;
- Undergone at NIV or HFNC since their admission
You likely can't join if
- Severe respiratory acidosis defined by pH\<7.25
- Decreased level of consciousness (Glasgow Coma Score Scale \< 11)
- Urgent intubation required
- Pneumothorax with pleural drainage and persistent air leak
- Hemodynamic instability requiring vasopressors
- Uncooperative
See the full eligibility criteria
- COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by
- Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);
- Respiratory rate≥20 breaths/min;
- Activation of accessory respiratory muscles;
- Undergone at NIV or HFNC since their admission
- English speaking
- Adult patient with age \> 40 year old.
- Severe respiratory acidosis defined by pH\<7.25
- Decreased level of consciousness (Glasgow Coma Score Scale \< 11)
- Urgent intubation required
- Pneumothorax with pleural drainage and persistent air leak
- Hemodynamic instability requiring vasopressors
- Uncooperative
- Patients with skin or chest wall or abdominal trauma (potentially worsened by placement of a surface sensor)
- Clinical judgement of the attending physician
- Body mass index \> 40 kg/m2
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.