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New treatment option for NonHodgkin Lymphoma
Official title Radiation Dose Optimization in Diffuse Large B- Cell Lymphoma.
ClinicalTrials.gov ID: NCT02964858
What this study is testing
- What it's testing
- The purpose of this study is to compare standard dose radiation of 45 Gray(Gy) in 25 fractions in Non Hodgkin's Lymphoma- Diffuse Large B cell Lymphoma (NHL-DLBCL) to that of 36 Gy in 20 fractions. The role of radiation in NHL-DLBCL has been addressed in large cooperative trials showing improvement in overall survival and progression free survival with combined modality treatment.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Histological Diagnosis of NHL- DLBCL.
- Eligible for RT after R-CHOP.
- ECOG 0-3.
- 18 - 65 years.
- Stage I-IV.
You likely can't join if
- Able to understand and willing to provide informed consent for participation in the trial. Exclusion Criteria:
- HIV positive status.
- Relapse or progression of disease during chemotherapy.
- Prior history of chemotherapy
- Prior history of radiotherapy.
- Systemic lymphomas with CNS involvement.
See the full eligibility criteria
- Histological Diagnosis of NHL- DLBCL.
- Eligible for RT after R-CHOP.
- ECOG 0-3.
- 18 - 65 years.
- Stage I-IV.
- Patients should receive at least 4 cycles of R-CHOP chemotherapy.
- Patients with all extranodal disease except the ones mentioned in the
- Able to understand and willing to provide informed consent for participation in the trial. Exclusion Criteria:
- HIV positive status.
- Relapse or progression of disease during chemotherapy.
- Prior history of chemotherapy
- Prior history of radiotherapy.
- Systemic lymphomas with CNS involvement.
- Primary extranodal Testicular Lymphomas.
- Primary extranodal central nervous system (CNS) Lymphomas.
- Primary extranodal Stomach DLBCL
- Primary extranodal Intestinal DLBCL
- Patients \>3 extranodal sites
The study team makes the final eligibility decision.
Where it's taking place
- Mumbai, Maharashtra, India
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mumbai, Maharashtra, India. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.