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New treatment option for Rectal Cancer
Official title Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker - Phase III Non CTIMP Trial
ClinicalTrials.gov ID: NCT02704520
What this study is testing
- What it's testing
- Open to patients undergoing any pre-operative treatment for locally advanced rectal cancer, TRIGGER is the only phase III clinical trial in the UK offering watch and wait. All patients will have post treatment MRI scans routinely performed, no change from the MERCURY trials high resolution MRI protocol is required.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 and older
You may be able to join if
- MRI defined locally advanced rectal carcinoma i.e. one or more: greater than or equal to mrT3c; mrEMVI positive; mr N1c; mr CRM positive
- Biopsy confirmed adenocarcinoma of radiologically defined rectum
- Be deemed to require preoperative chemoradiotherapy (CRT) or total neoadjuvant therapy (TNT)
You likely can't join if
- Metastatic disease
- MRI, radiotherapy and/or chemotherapy contraindications
- A post-treatment MRI performed more than 10 weeks after the completion of radiotherapy if given
- Previous malignancy within preceding 5 years if risk of recurrence \>5%
The study team makes the final eligibility decision.
Where it's taking place
- Aberdeen, Aberdeenshire, United Kingdom
- Basingstoke, Hampshire, United Kingdom
- Stoke-on-Trent, Staffordshire, United Kingdom
- Salisbury, Wiltshire, United Kingdom
- Bristol, United Kingdom
- Colchester, United Kingdom
- East Kilbride, United Kingdom
- Grimsby, United Kingdom
- Stockton-on-Tees, United Kingdom
- Sutton, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aberdeen, Aberdeenshire, United Kingdom; Basingstoke, Hampshire, United Kingdom; Stoke-on-Trent, Staffordshire, United Kingdom; Salisbury, Wiltshire, United Kingdom; Bristol, United Kingdom; Colchester, United Kingdom and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.