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New treatment option for Stress Disorders, Post-Traumatic
Official title Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
ClinicalTrials.gov ID: NCT02560805
What this study is testing
What is Sodium Nitroprusside (SNP)?
Sodium Nitroprusside (SNP) is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for stress disorders, post-traumatic.
Also referred to as Nitropress.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.
You likely can't join if
- pregnancy
- hypertension
- diabetes
- heart or vascular disease
- illicit drug use
- excessive alcohol use (\>2 drinks per day)
See the full eligibility criteria
- veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.
- pregnancy
- hypertension
- diabetes
- heart or vascular disease
- illicit drug use
- excessive alcohol use (\>2 drinks per day)
- hyperlipidemia
- autonomic dysfunction
- current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE) inhibitors, or angiotensin II receptor blockers (ARBs)
- treatment with monoamine oxidase (MAO) inhibitors within the last 14 days
- any serious systemic disease
- chronic kidney disease defined as estimated glomerular filtration rate (GFR) \< 60 cc/min
- hyperkalemia (serum potassium \> 5 meq/dL)
- systolic blood pressure \< 100 mm Hg
- diastolic blood pressure \< 60 mm Hg
- heart rate \< 50 beats/min
- known hypersensitivity to ARBs or beta blockers
The study team makes the final eligibility decision.
Where it's taking place
- Decatur, Georgia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Decatur, Georgia, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.