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New treatment option for Liposarcoma, Myxoid
Official title Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients
ClinicalTrials.gov ID: NCT02275286
What this study is testing
What is Trabectedin?
Trabectedin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for liposarcoma, myxoid.
Also referred to as Yondelis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Phase I-II trial that combines trabectedin plus radiotherapy for tumor reduction response measure in four cohorts of patients: Cohort A: Patients with diagnosis of non-operable or unresectable or not oncologically recommended metastasectomy of limited to lung metastases soft tissue sarcoma. Cohort B: Patients with locally advanced resectable Myxoid Liposarcoma.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Cohort A: STS
- The patient must sign voluntarily the informed consent form before any study test is conducted that is not part of routine patient care.
- Aged equal or over 18.
- Patients must have a diagnostic of Soft Tissue Sarcoma with metastasis limited to lung, and not suitable for metastasectomy or surgery resection or...
- Disease distribution allows meeting with normal tissue constraints of radiation therapy. Radiation oncologist must confirm this point.
You likely can't join if
- Previous treatment with trabectedin or previous treatment with radiotherapy (except if previous radiotherapy treatment plus planned study...
- Performance status ≥ 2 (ECOG).
- Plasma bilirubin \> UNL.
- Creatinine \> 1.6 mg/dL.
- History of other neoplastic disease with less than 5 years free of disease with the exception of basal cell carcinoma or in situ cervical cancer...
- Severe COPD or other severe pulmonary diseases.
See the full eligibility criteria
Who can join
- Cohort A: STS
- The patient must sign voluntarily the informed consent form before any study test is conducted that is not part of routine patient care.
- Aged equal or over 18.
- Patients must have a diagnostic of Soft Tissue Sarcoma with metastasis limited to lung, and not suitable for metastasectomy or surgery resection or not oncologically recommended metastasectomy.A centralized diagnostic...
- Disease distribution allows meeting with normal tissue constraints of radiation therapy. Radiation oncologist must confirm this point.
- Metastatic spread could be present in two organs at maximum (i.e. lungs and pelvic fosa).
- Those lesions considered for radiation therapy have to be considered as target lesions as well. (i.e. in a patient with nodules in lungs, those lesions selected for radiation therapy have to include at least the target...
- It is allowed that not all the lesions will be under radiation fields. As a general rule, it will be prioritized to select, as target-irradiating lesions, those with greater increase in size and those largest lesions...
- Patients must have documentation of disease progression within 6 months prior to study entry.
- The patient must have been considered eligible for systemic chemotherapy. A maximum of two previous lines for advanced/metastatic disease are allowed as long as trabectedin has not been included.
- The following histological subtypes can be included: Undifferentiated pleomorphic sarcoma (previously, malignant fibrous histiocytoma) Leiomyosarcoma Angiosarcoma/ epithelial hemangioendothelioma Liposarcoma and its...
- Measurable disease, according to RECIST V 1.1 criteria
- Performance status ≤1 (ECOG).
- Adequate respiratory functions: FEV1 \>1L; DLco \> 40% (patients with pulmonary target lesions)
- Adequate bone marrow function (hemoglobin \> 10 g/dl, leukocytes ≥ 3.000/mm3, neutrophils ≥ 1.500/mm3, platelets ≥ 100.000/mm3). Patients with plasma creatinine ≤ 1,6 mg/dl, transaminases ≤ 2.5 times the UNL, total...
- Men or women of child bearing potential should be using an effective method of contraception before entry into the study and throughout the same and for 6 months after ending the study. Women of childbearing potential...
- Normal cardiac function with a LVEF ≥ 50% by echocardiogram or MUGA.
- It should be performed HBV and HCV serologies prior to inclusion. If HbsAg is positive it is recommended to reject the existence of replicative phase (HbaAg+, DNA VHB+). If these were positives the inclusion is not...
- Patient must have a Central Venous Catheter for treatment
What rules you out
- Previous treatment with trabectedin or previous treatment with radiotherapy (except if previous radiotherapy treatment plus planned study radiotherapy treatment allow tissues constrains)
- Performance status ≥ 2 (ECOG).
- Plasma bilirubin \> UNL.
- Creatinine \> 1.6 mg/dL.
- History of other neoplastic disease with less than 5 years free of disease with the exception of basal cell carcinoma or in situ cervical cancer adequately treated.
- Severe COPD or other severe pulmonary diseases.
- Significant cardiovascular disease (for example, dyspnea \> 2 NYHA)
- Significant systemic diseases grade 3 or higher on the NCI-CTCAE v4.03 scale, that limit patient availability, or according to investigator judgment may contribute significantly to treatment toxicity.
- Uncontrolled bacterial, mycotic or viral infections.
- Known positive test for infection by human immunodeficiency virus (HIV).
- Women who are pregnant or breast-feeding.
- Psychological, familial, social or geographic circumstances that limit the patient"s ability to comply with the protocol or informed consent.
- Patients participating in another clinical trial or receiving any other investigational product
- Patients who had participated in another clinical trial and/or had received any other investigational product in the last 30 days prior to inclusion.
- Histologies other than those described in inclusion criteria. Cohort B: ML Inclusion criteria:
- The patient must sign voluntarily the informed consent form before any study test is conducted that is not part of routine patient care.
- Age ≥18 years old.
- Pathological diagnosis of Myxoid Liposarcoma, deep located and more than 5 cm or superficial more than 10 cm. A centralized diagnostic will be performed to confirm that the patient can be included in the study.
- Tumor must be resectable and without evidence of regional or distal spread after adequate staging procedure. Tumor must be located in limbs or superficial trunk wall.
- Disease distribution allows meeting with normal tissue constraints of radiation therapy. Radiation oncologist must confirm this point.
- Measurable disease, according to RECIST V 1.1 criteria
- Performance status 0-1 (ECOG).
- Adequate bone marrow function (hemoglobin \> 10 g/dL, leukocytes ≥ 3.000/mm3, neutrophils ≥ 1.500/mm3, platelets ≥ 100.000/mm3). Patients with plasma creatinine ≤ 1,6 mg/dL, transaminases ≤ 2.5 times the UNL, total...
- Men or women of child bearing potential should be using an effective method of contraception before entry into the study and throughout the same and for 6 months after ending the study. Women of childbearing potential...
- Normal cardiac function with a LVEF ≥ 50% by echocardiogram or MUGA.
- It should be performed HBV and HCV serologies prior to inclusion. If HbsAg is positive it is recommended to reject the existence of replicative phase (HbaAg+, DNA HBV+). If these were positives the inclusion is not...
- Patient may have had one previous chemotherapy line.
- Patient must have a Central Venous Catheter for treatment. Exclusion criteria:
- Unresectable tumors (with limb sparing surgery)
- More than one previous chemotherapy treatment for local disease including trabectedin.
- Radiotherapy involving the tumoral bed.
- Performance status ≥ 2 (ECOG).
- Presence of metastases or lymph node involvement by the tumor.
- Location other than limb or superficial trunk wall.
- Plasma bilirubin \> UNL.
- Creatinine \> 1.6 mg/dL.
- History of other neoplastic disease with less than 5 years free of disease with the exception of basal cell carcinoma or in situ cervical cancer adequately treated.
- Significant cardiovascular disease (for example, dyspnea \> 2 NYHA)
- Significant systemic diseases grade 3 or higher on the NCI-CTCAE v4.03 scale, that limit patient availability, or according to investigator judgment may contribute significantly to treatment toxicity.
- Uncontrolled bacterial, mycotic or viral infections.
- Known positive test for infection by human immunodeficiency virus (HIV).
- Women who are pregnant or breast-feeding.
- Psychological, familial, social or geographic circumstances that limit the patient"s ability to comply with the protocol or informed consent.
- Patients who had participated in another clinical trial and/or had received any other investigational product in the last 30 days prior to inclusion. Cohorts C and D: Retroperitoneum sarcoma Inclusion criteria:
- The patient must voluntarily sign the informed consent form before performing any study-specific test that is not part of the patient's usual care.
- Aged between 18 and 75 years.
- The following histological subtypes may be included in the cohort C: High grade leiomyosarcoma (G2-3), liposarcoma (G2-3), if at least 30% of the tumour is dedifferentiated, pleomorphic liposarcoma. The following...
- The tumour must be located in the retroperitoneum and it must be resectable and without evidence of regional or distal spread after the appropriate staging process. This point must be confirmed by the central surgeon...
- The location and size of the disease in the retroperitoneum must allow for compliance with radiotherapy limitations in healthy tissue. This point must be confirmed by the site's radiation oncologist and the central...
- Measurable disease according to CHOI criteria for cohort C and RECIST V 1.1 criteria for cohort D.
- ECOG performance status 0-1.
- Adequate haematological parameters (haemoglobin \>10 g/dl, leukocytes ≥3,000/mm3, neutrophils ≥1,500/mm3, platelets ≥100,000/mm3). Patients with plasma creatinine ≤1.6 mg/dl, transaminases ≤2.5 times the ULN, total...
- Fertile men or women must use an effective contraceptive method before starting the study, during the study and for 6 months following the conclusion thereof. Women of childbearing potential who participate in the study...
- Normal cardiac function with LVEF ≥50% by echocardiogram or MUGA.
- HBV and HCV serology must be performed before including the patient in the study. If HbsAg is positive, it is advisable to rule out a replicative phase (HbsAg\ , DNA HBV+). If positive, the patient's inclusion in the...
- Patient may have had one previous chemotherapy line (cohort D only).
- The patient must have a central venous catheter for the administration of the treatment. Exclusion criteria
- Unresectable tumours.
- Location other than the retroperitoneum.
- Patients who have previously received systemic treatment with chemotherapy (trabectedin included). For cohort D, patients may have received one previous line of chemotherapy with any other agent.
- Patients who underwent prior local treatment for retroperitoneal sarcoma: surgery or radiotherapy in the tumour bed.
- ECOG performance status ≥2.
- Presence of metastasis or lymph node involvement of the tumour.
- Previous history of another neoplastic disease with less than 5 years free of disease except for basal cell carcinoma or properly treated in situ cervical cancer.
- Significant cardiovascular disease (e.g. dyspnoea \>2 NYHA).
- A significant grade 3 or greater systemic disease on the NCI-CTCAE v4.03 scale, which may limit the availability of the patient or which, in the opinion of the investigator, may contribute to the toxicity caused by the...
- Uncontrolled viral, mycotic or bacterial infections.
- Known HIV-positive patients.
- Pregnant or breast-feeding women.
- Psychological, familial, social or geographical circumstances that limit the patient's ability to comply with the protocol or informed consent form.
- Patients who have participated in another clinical trial and/or have received another investigational product in the 30 days prior to inclusion in the trial.
The study team makes the final eligibility decision.
Where it's taking place
- Bordeaux, France
- Lyon, France
- Rozzano, Milan, Italy
- Aviano, Italy
- Bologna, Italy
- Candiolo, Italy
- Milan, Italy
- Zaragoza, Aragon, Spain
- Barcelona, Catalonia, Spain
- Palma de Mallorca, Mallorca, Spain
- San Cristóbal de La Laguna, Tenerife, Spain
- Barcelona, Spain
- Madrid, Spain
- Seville, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bordeaux, France; Lyon, France; Rozzano, Milan, Italy; Aviano, Italy; Bologna, Italy; Candiolo, Italy and 8 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.