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COLOVERT – Conversion therapy in colorectal cancer with peritoneal metastases not amenable to upfront cytoreductive surgery and HIPEC: a phase II “pick-the-winner” open-label randomized trial
EU CTIS ID: 2026-526122-41-00
What this study is testing
To compare the difference in objective response rates (ORR) between two experimental repeat intraperitoneal chemotherapy regimens.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- • Provision of written informed consent prior to any study specific procedures. • ECOG Performance Status Score 0,1 or 2 alternatively Karnofsky 60-100 • Adequate kidney, liver, bone marrow function according to laboratory tests • For females of childbearing potential, a negative pregnancy test must be documented. • ≥ 18 years old and <80 years old • Colorectal cancer (>10cm from anal verge) with CT assessable synchronous or metachronous peritoneal metastases +/- primary tumor • CT-PCI > 10 (which translates often to surgical PCI >15) as judged at the HIPEC multidisciplinary board meeting but considered candidate for CRS/HIPEC in the case of significant tumor response. • CT-PCI < 10 allowed if conversion therapy is necessary to be eligible for CRS+/-HIPEC • RAS mutations and wild-type cancers can both be included. • No previous treatment for peritoneal metastatic disease
You likely can't join if
- • Previous severe toxicity/allergic reactions to the systemic chemotherapy agents included in this study • Unable to tolerate full dose systemic chemotherapy treatment due to comorbidity or previous remaining toxicity (e.g. neurotoxicity) or DPYD deficiency • Deficient mismatch repair cancers are excluded • Previous CRS or HIPEC or other large open abdominal surgery leading to significant intraperitoneal adhesions. (laparoscopic procedures are ok) • Previous severe abdominal septicemia or other causes that may significantly increase the risk of intraperitoneal adhesions (a staging laparoscopy may be allowed to determine this) • Pregnant or lactating (nursing) women • Active infections requiring antibiotics • Active liver disease with positive serology for active hepatitis B, C, or known HIV • Concurrent administration of any cancer therapy other than planned study treatment within 4 weeks prior to and up to 4 weeks after study treatment • Lower and intermediate rectal cancers are excluded (above >10cm accepted) • Indication for preoperative radiation
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.