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IMPACT-NAC: A clinical trial of N-acetylcysteine for adults with severe infection and liver dysfunction
EU CTIS ID: 2026-525895-25-00
What this study is testing
To assess the effects of N-acetylcysteine on mortality and hospital length of stay in adults admitted to the emergency department with acute infection or sepsis and evidence of liver dysfunction.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age ≥18 years
- Documented clinical suspicion of infection
- Model for end-stage liver disease (MELD) score ≥9
You likely can't join if
- Admitted to hospital >24 hours before randomization
- Documented clinical suspicion of bile duct obstruction
- Refractory circulatory shock
- Inability to provide informed consent
- Pregnancy
- Inability to read and understand Danish to a degree that allows valid informed consent and completion of trial assessments
See the full eligibility criteria
- Age ≥18 years
- Documented clinical suspicion of infection
- Model for end-stage liver disease (MELD) score ≥9
- Admitted to hospital >24 hours before randomization
- Documented clinical suspicion of bile duct obstruction
- Refractory circulatory shock
- Inability to provide informed consent
- Pregnancy
- Inability to read and understand Danish to a degree that allows valid informed consent and completion of trial assessments
- Involuntary admission under the psychiatric law
- Any other condition deemed by the investigator to compromise patient safety or trial integrity (e.g., severe coagulopathy, uncontrolled bleeding, diabetic ketoacidosis)
- Expected initiation of palliative care within 48 hours of randomization
- Ongoing treatment with nitroglycerin
- Any previous severe anaphylaxis
- Known allergy to N-acetylcysteine
- Ongoing treatment with N-acetylcysteine at randomization
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.