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Effect of vasopressin versus norepinephrine on post-operative mean pulmonary arterial pressure following pulmonary endarterectomy surgery, a randomized open label trial
EU CTIS ID: 2025-525153-39-00
What this study is testing
To compare the efficacy of vasopressin versus norepinephrine on the immediate post-operative reduction in mean pulmonary arterial pressure (mPAP) following pulmonary artery endarterectomy.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age ≥18 years;
- Patient scheduled for pulmonary endarterectomy surgery;
- In women of childbearing potential: negative serum pregnancy test and use of adequate contraception;
- Affiliation to the French social care service;
- Patient able to understand and sign a written informed consent form.
You likely can't join if
- Emergency surgery;
- Mesenteric ischemia and/or acute coronary syndrome within the month preceding the intervention;
- Known allergy to the active substance vasopressin or to any of its excipients;
- Concomitant coronary bypass procedure or other combined surgery (i.e. valve replacement);
- mPAP<25 mmHg on preoperative right heart catheterization;
- Patient participating to another interventional clinical trial;
See the full eligibility criteria
- Age ≥18 years;
- Patient scheduled for pulmonary endarterectomy surgery;
- In women of childbearing potential: negative serum pregnancy test and use of adequate contraception;
- Affiliation to the French social care service;
- Patient able to understand and sign a written informed consent form.
- Emergency surgery;
- Mesenteric ischemia and/or acute coronary syndrome within the month preceding the intervention;
- Known allergy to the active substance vasopressin or to any of its excipients;
- Concomitant coronary bypass procedure or other combined surgery (i.e. valve replacement);
- mPAP<25 mmHg on preoperative right heart catheterization;
- Patient participating to another interventional clinical trial;
- For females only: documented pregnancy or lactation;
- Patient under tutorship, curatorship or legal protection
- Patient deprived of liberty.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.