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Diving into the noradrenergic system : Role of the alpha2C-adrenergic receptors NA2C-TEP-IRM
EU CTIS ID: 2025-524602-15-00
What this study is testing
The primary objective of the NA2C-PET-MRI study is to evaluate in vivo, using the radiotracer [¹¹C]ORM-13070, the effect of normal aging and Parkinson's disease on the availability of α₂C-adrenergic receptors in the human brain.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Healthy volunteers : Age between 20 years and 80 years
- Patients : Weight between 40kg and 100kg
- Patients : With an idiopathic Parkinson’s disease (Dopa-sensitive)
- Patients : Without head trauma history including loss of consciousness superior to 30 minutes
- Patients : Without associated neurological pathology
- Patients : With highly effective contraception for women of childbearing age
You likely can't join if
- Subject receiving (or having received in the last month) somatic medication with cerebral or psychological effects (e.g., antihistamines)
- Persons receiving psychiatric care
- Persons admitted to a health or social care facility for purposes other than research
- Subjects with a current or past dependence on alcohol or any other addictive substance according to DSM-IV-TR criteria, with the exception of nicotine and caffeine
- Subjects already participating in another biomedical research project or who have participated in a study using ionizing radiation within the past year
- Pregnant woman parturient or breastfeeding
See the full eligibility criteria
- Healthy volunteers : Age between 20 years and 80 years
- Patients : Weight between 40kg and 100kg
- Patients : With an idiopathic Parkinson’s disease (Dopa-sensitive)
- Patients : Without head trauma history including loss of consciousness superior to 30 minutes
- Patients : Without associated neurological pathology
- Patients : With highly effective contraception for women of childbearing age
- Patients : Affiliated to a social security or similar scheme
- Patients : Not subject to any legal protection measures
- Patients : Participant must have signed an informed consent document
- Healthy volunteers : Weight between 40kg and 100kg
- Healthy volunteers : Without neurologic or psychiatric history
- Healthy volunteers : Without head trauma history including loss of consciousness superior to 30 minutes
- Healthy volunteers : With highly effective contraception for women of childbearing age
- Healthy volunteers : Affiliated to a social security or similar scheme
- Healthy volunteers : Not subject to any legal protection measures
- Healthy volunteers : Participant must have signed an informed consent document
- Patients : Age between 40 years and 80 years
- Subject receiving (or having received in the last month) somatic medication with cerebral or psychological effects (e.g., antihistamines)
- Persons receiving psychiatric care
- Persons admitted to a health or social care facility for purposes other than research
- Subjects with a current or past dependence on alcohol or any other addictive substance according to DSM-IV-TR criteria, with the exception of nicotine and caffeine
- Subjects already participating in another biomedical research project or who have participated in a study using ionizing radiation within the past year
- Pregnant woman parturient or breastfeeding
- MRI contraindications : people using pacemaker or insulin pumps, with implanted or embedded metal objects in the head or body, claustrophobic, with neurosensory stimulators or implantable defibrillators, with cochlear implants, with ferromagnetic foreign bodies in the eye or brain close to nerve structures, agitation of the subject (uncooperative or agitated subjects), ventriculoperitoneal neurosurgical shunt valves, dental appliances
- Subject with a contraindication to PET scans at the ORM : hypersensitivity to the active substance or to any of the excipients (sodium chloride)
- Subjects who are unable to understand or complete the study (language barrier, obvious lack of motivation, etc.) as judged by the investigator
- Subjects who do not agree to be informed in the event of an incidental finding of an abnormality on MRI or during neuropsychological assessment
- Persons deprived of their liberty by judicial or administrative decision
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.