A phase IV trial of Shingrix on incident dementia diagnosis in adults aged ≥76 years in Finland

You likely can't join if

• Participants will be excluded from the study if any of the following criteria apply: 1. History of vaccination against HZ
• 2. History of dementia prior to enrolment, including confirmed cases or those under investigation. This includes: a) History of a confirmed clinical diagnosis of dementia prior to enrolment b) Prior or current use of medications intended to treat dementia c) Current or recent history of cognitive assessments for any memory deficit or suspected dementia before enrollment including investigations that are ongoing or were inconclusive (but not those for which dementia was conclusively ruled out); MCI on its own without any other information to indicate cognitive decline or dementia will not result in exclusion
• 3. Severely immunocompromised individuals (i.e., those with haematological cancer or have had stem cell transplant or organ transplant)
• 4. Concurrently participating in another clinical trial, in which the participant has been or will be exposed to an investigational product
• 5. Known systemic hypersensitivity to any of the vaccine components, or history of a life-threatening reaction to the vaccines used in the study or to a vaccine containing any of the same substances
• 6. Living in a nursing facility