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Progesterone supplementation after letrozole-stimulated insemination
EU CTIS ID: 2025-524327-53-00
What this study is testing
To investigate if luteal phase support with a standard dose of vaginal progesterone increases the clinical pregnancy rates following mild ovarian stimulation with letrozole in infertile women undergoing IUI
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age 18-37 years
- Scheduled for intrauterine insemination with homologous or donor sperm
- Undergoing mild ovarian stimulation with letrozole
- Ability to provide written informed consent
You likely can't join if
- Age > 37 years
- Anovulation due to hypogonadotropic hypogonadism
- Known hypersensitivity to progesterone or to hard fat listed as an excipient in the Summary of Product Characteristics (SmPC) for Cyclogest.
- Known or suspected progesterone-sensitive malignant tumours
- Porphyria
- Known missed abortion or ectopic pregnancy
See the full eligibility criteria
- Age 18-37 years
- Scheduled for intrauterine insemination with homologous or donor sperm
- Undergoing mild ovarian stimulation with letrozole
- Ability to provide written informed consent
- Age > 37 years
- Anovulation due to hypogonadotropic hypogonadism
- Known hypersensitivity to progesterone or to hard fat listed as an excipient in the Summary of Product Characteristics (SmPC) for Cyclogest.
- Known or suspected progesterone-sensitive malignant tumours
- Porphyria
- Known missed abortion or ectopic pregnancy
- Active arterial or venous thromboembolism, severe thrombophlebitis, or a history of these conditions
- Severe hepatic dysfunction or liver disease
- Inability to speak or understand Danish sufficiently to comprehend oral and written study information
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.