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ARMYDA - 10 study
EU CTIS ID: 2025-523977-40-00
What this study is testing
This study aims to evaluate anti-inflammatory actions of oral semaglutide within coronary plaques by measuring changes in the macrophage arc.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- - Diagnosis of T2DM - Non-ST-segment elevation ACS - Presence of one identifiable culprit coronary lesion treated with percutaneous coronary intervention (PCI) - Presence of at least one non-culprit, mild to intermediate stenosis (30% to 69% lumen narrowing) at coronary angiography, with a macrophage arc detectable on optical coherence tomography (OCT), on a major epicardial coronary artery different from the culprit vessel - Age ≥40 years - Signed informed consent.
You likely can't join if
- - Acute heart failure - Renal dysfunction (estimated GFR <30 mL/min/1.73 m²) or dialysis - History or high risk of pancreatitis. - Severe gastroparesis requiring therapy <6 months prior to randomization. - Active malignancy or history of neuroendocrine tumors. - Hypersensitivity or contraindications to semaglutide or its excipients. - Severe hepatic dysfunction (ALT/AST >2× upper limit of normal or total bilirubin >1.5× upper limit of normal). - Pregnancy or breastfeeding. Women of childbearing potential must have a negative pregnancy test at screening and agree to use effective contraception during the study. - Patients with diabetic ketoacidosis - Use of semaglutide at screening within 30 days prior to randomization. - Inability to provide informed consent.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.