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Changes in the wound microbiome and their impact on chronic wound healing under hyperbaric conditions
EU CTIS ID: 2025-523863-39-00
What this study is testing
To evaluate the impact of Hyperbaric Oxygen Therapy (HBOT) on the diversity and composition of the wound microbiome in chronic wound patients
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- • Age 18 years or older
- • Diagnosis of a chronic wound (e.g., diabetic ulcer, vascular ulcer, or pressure ulcer) persisting for over one month despite standard wound care.
- • Willingness and ability to undergo a minimum of 30 HBOT sessions over 6 weeks.
- • Suitability for HBOT, determined by meeting standard HBO suitability criteria.
- • Provision of informed consent to participate in the study
You likely can't join if
- • Concurrent participation in another clinical trial affecting wound healing or microbiome.
- • Acute wounds or wounds from infectious diseases outside the specified inclusion (e.g., osteomyelitis).
- • Contraindications to HBOT (e.g., untreated pneumothorax, severe claustrophobia).
- • Conditions impairing immune function (e.g., active HIV/AIDS, current chemotherapy).
- • Pregnancy or breastfeeding.
- • Current use of disulfiram (Antabuse®), due to its potential inhibition of superoxide dismutase and the resulting, as yet unquantified, theoretical increased risk of oxygen toxicity during HBOT
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.