BridgeMD
SAVE trial
EU CTIS ID: 2025-523709-13-00
What this study is testing
Compare the final volume of cerebral infarction by magnetic resonance imaging at 72 hours in patients with acute ischemic stroke undergoing mechanical thrombectomy under general anesthesia, who are randomly assigned to receive anesthetic maintenance with sevoflurane or propofol.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age >18 years
- Acute ischemic stroke within 24 hours from the last time seen well (LTSW), undergoing emergency endovascular treatment (EVT), with or without prior thrombolysis.
- Intracranial occlusion in the anterior circulation, including occlusions in segments M1 and M2 of the middle cerebral artery and/or the terminal portion of the internal carotid artery (TICA). Tandem lesions affecting extracranial segments of the internal carotid artery will also be included.
- Alberta Stroke Program Early CT Score (ASPECTS) ≥6 on baseline computed tomography (CT).
- Pre-stroke modified Rankin Scale (mRS) score of 0–3.
- Indication for general anesthesia at the start of the procedure (<30 minutes from femoral puncture) due to one of the following reasons: • Confusion or lack of patient cooperation. • Technical difficulties, such as complex arterial access, vascular tortuosity, need for extra- or intracranial stent placement, distal/medium vessel occlusions, among others. • Treating team's preference.
You likely can't join if
- Presence of hemorrhagic lesions on baseline CT.
- Occlusions in the anterior cerebral artery (ACA).
- Occlusions in the posterior circulation, including vertebral, basilar, or posterior cerebral arteries (PCA).
- Hemodynamic instability.
- Acute respiratory failure requiring orotracheal intubation
- Decision to perform general anesthesia due to complications during the endovascular treatment.
See the full eligibility criteria
- Age >18 years
- Acute ischemic stroke within 24 hours from the last time seen well (LTSW), undergoing emergency endovascular treatment (EVT), with or without prior thrombolysis.
- Intracranial occlusion in the anterior circulation, including occlusions in segments M1 and M2 of the middle cerebral artery and/or the terminal portion of the internal carotid artery (TICA). Tandem lesions affecting extracranial segments of the internal carotid artery will also be included.
- Alberta Stroke Program Early CT Score (ASPECTS) ≥6 on baseline computed tomography (CT).
- Pre-stroke modified Rankin Scale (mRS) score of 0–3.
- Indication for general anesthesia at the start of the procedure (<30 minutes from femoral puncture) due to one of the following reasons: • Confusion or lack of patient cooperation. • Technical difficulties, such as complex arterial access, vascular tortuosity, need for extra- or intracranial stent placement, distal/medium vessel occlusions, among others. • Treating team's preference.
- Ability of the patient or the family member/legal representative to provide informed consent.
- Presence of hemorrhagic lesions on baseline CT.
- Occlusions in the anterior cerebral artery (ACA).
- Occlusions in the posterior circulation, including vertebral, basilar, or posterior cerebral arteries (PCA).
- Hemodynamic instability.
- Acute respiratory failure requiring orotracheal intubation
- Decision to perform general anesthesia due to complications during the endovascular treatment.
- Known hypersensitivity to propofol, sevoflurane, or any of their excipients.
- Personal or family history of malignant hyperthermia, or suspected susceptibility to malignant hyperthermia (contraindication to halogenated anesthetics such as sevoflurane).
- History of a previous severe adverse reaction to halogenated anesthetics, including hepatotoxicity associated with their use.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.