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Evaluation of the effect of intravenous lidocaine on the systemic inflammatory response associated with cardiopulmonary bypass in patients undergoing elective valvular and coronary cardiac surgery: A randomized double-blind clinical trial.
EU CTIS ID: 2025-523534-11-00
What this study is testing
To evaluate whether intravenous administration of lidocaine reduces blood interleukin-6 (IL-6) levels at 6 hours after the end of surgery in patients undergoing elective cardiac valve and/or coronary artery bypass surgery with cardiopulmonary bypass.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients must meet ALL of the following criteria to be included in the study: 1. Age > 18 years. 2. Scheduled (elective) surgery. 3. Valvular and/or coronary surgery (repair or replacement). 4. Use of cardiopulmonary bypass. 5. Provision of informed consent, after receiving adequate information about the study.
You likely can't join if
- Patients presenting ANY of the following criteria will not be eligible to participate in the study: 1. Chronic treatment with systemic corticosteroids within the 90 days prior to surgery. 2. Acute coronary syndrome within the last 10 days. 3. Hepatic failure Child-Pugh C. 4. Severe renal impairment (glomerular filtration rate < 30 mL/min). 5. Use of cytokine filter during cardiopulmonary bypass. 6. Active infection requiring systemic antibiotic treatment, including endocarditis during the hospital admission prior to surgery. 7. Pregnancy or breastfeeding. 8. Known allergy to lidocaine or any amide-type local anaesthetic. 9. Medical or surgical history which, in the investigator’s opinion, precludes participation in the study.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.