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CoCo3 - Comprehensive Health Effects of Combined Contraceptives: a 12-month randomized, controlled, open-label trial comparing E4+DRSP, EE 20μg+DRSP and DRSP-only
EU CTIS ID: 2025-523359-71-00
What this study is testing
The main objective of the study is to investigate whether E4+DRSP has a lesser impact on coagulation, measured by endogenous thrombin potential (ETP), than EE+DRSP. We hypothesize that DRSP-only does not significantly alter the in vitro coagulation-related outcomes.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age: 18-40 years when entering the trial
- Willingness to use trial medication and to sign a written informed consent
- BMI: 18-29.9 kg/m2
- Healthy, no clinically significant illnesses diagnosed by a health care provider, nor any continuous medical treatment
- Regular menstrual cycle
- Two-month withdrawal time from previous use of hormonal contraceptive medication
You likely can't join if
- Any contraindication for the use of combined contraceptives
- Clinically significant abnormalities in screening measurements or ultrasound
- Regular smoking/use of nicotine products, illicit drugs, or alcohol abuse
- The aim of becoming pregnant during the study period
- Any disease or condition that may interfere with the conduct of the study or the interpretation of the results
See the full eligibility criteria
- Age: 18-40 years when entering the trial
- Willingness to use trial medication and to sign a written informed consent
- BMI: 18-29.9 kg/m2
- Healthy, no clinically significant illnesses diagnosed by a health care provider, nor any continuous medical treatment
- Regular menstrual cycle
- Two-month withdrawal time from previous use of hormonal contraceptive medication
- Minimum of three months from pregnancy or breastfeeding
- Sufficient knowledge of Finnish to understand research documents and to communicate with research staff
- Any contraindication for the use of combined contraceptives
- Clinically significant abnormalities in screening measurements or ultrasound
- Regular smoking/use of nicotine products, illicit drugs, or alcohol abuse
- The aim of becoming pregnant during the study period
- Any disease or condition that may interfere with the conduct of the study or the interpretation of the results
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.