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Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial
EU CTIS ID: 2025-523071-34-00
What this study is testing
Compare the analgesic efficacy between Geniculate Nerve Blocks versus the combination of IPACK (infiltration between the popliteal artery and the capsule of the knee) and Adductor Canal Blocks in patients undergoing primary total knee replacement (TKR). This will be evaluated during the first physiotherapy session at 24 hours postoperatively, using the Numerical Rating Scale (NRS) for pain assessment.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- All patients undergoing primary total knee arthroplasty who provide consent to participate in the study and whose attending surgeon also agrees to the study.
- ASA physical status classification I-III.
- BMI 18-40 kg/m2.
You likely can't join if
- Patients who refuse to undergo the block procedure, who refuse to give their consent, or who are unable to cooperate with protocol compliance.
- Patients in whom the total dose of local anesthetic exceeds the calculated toxic dose based on their ideal body weight.
- Patients requiring general anesthesia.
- Age younger than 18 years or older than 90 years.
- Patients undergoing bilateral arthroplasty, revision arthroplasties, or prosthetic replacements.
- Contraindication for peripheral nerve block (local infection, neurological deficit, complex regional pain syndrome, previous trauma, or surgery on the ipsilateral knee).
See the full eligibility criteria
- All patients undergoing primary total knee arthroplasty who provide consent to participate in the study and whose attending surgeon also agrees to the study.
- ASA physical status classification I-III.
- BMI 18-40 kg/m2.
- Patients who refuse to undergo the block procedure, who refuse to give their consent, or who are unable to cooperate with protocol compliance.
- Patients in whom the total dose of local anesthetic exceeds the calculated toxic dose based on their ideal body weight.
- Patients requiring general anesthesia.
- Age younger than 18 years or older than 90 years.
- Patients undergoing bilateral arthroplasty, revision arthroplasties, or prosthetic replacements.
- Contraindication for peripheral nerve block (local infection, neurological deficit, complex regional pain syndrome, previous trauma, or surgery on the ipsilateral knee).
- Systemic infection.
- Consumption of opioids during the last 4 weeks at doses greater than 30 mg of oral morphine or equivalent.
- Patients with a hemorrhagic diathesis or coagulopathy (diagnosed by medical history or laboratory tests).
- Patients with allergies to any medication that is part of the protocol (e.g., allergy to local anesthetics).
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.