BridgeMD
The REVERT-PREDIABETES trial
EU CTIS ID: 2025-522970-35-00
What this study is testing
To examine the proportion of patients with angiographically documented coronary artery disease that can be reverted from prediabetes to normoglycemia by using cardioprotective glucose-lowering drugs.
- Phase III and phase IV (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Chronic coronary syndrome with documented coronary artery disease. In the case of previous myocardial infarction, at least 30 days between the event and randomization is required.
- Prediabetes defined as HbA1c 42-47 mmol/mol OR normoglycemia defined as HbA1c <39 mmol/mol
- Age 18 to 80 years
You likely can't join if
- eGFR <30 mL/min/1.73 m2
- Heart failure with NYHA class III or IV
- Previous diabetes diagnosis, previous HbA1c >47 mmol/mol, or current/previous usage of diabetes medication
- Anemia, recent bleeding or blood transfusion (<3 months)
- Previous pancreatitis
- Pregnancy, breastfeeding, or fertile women who do not use highly effective birth control
See the full eligibility criteria
- Chronic coronary syndrome with documented coronary artery disease. In the case of previous myocardial infarction, at least 30 days between the event and randomization is required.
- Prediabetes defined as HbA1c 42-47 mmol/mol OR normoglycemia defined as HbA1c <39 mmol/mol
- Age 18 to 80 years
- eGFR <30 mL/min/1.73 m2
- Heart failure with NYHA class III or IV
- Previous diabetes diagnosis, previous HbA1c >47 mmol/mol, or current/previous usage of diabetes medication
- Anemia, recent bleeding or blood transfusion (<3 months)
- Previous pancreatitis
- Pregnancy, breastfeeding, or fertile women who do not use highly effective birth control
- Strongly reduced liver function
- Chronic alcohol abuse
- Known hemoglobinopathy and other conditions with effect on erythrocyte lifespan
- Intake of medications with known effect on HbA1c validity
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.