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Which is the best treatment to relieve severe acute pain in the prehospital phase : Morphine or alfentanil ?
EU CTIS ID: 2025-522817-50-00
What this study is testing
To compare the analgesic efficacy 15 minutes after intravenous injection of morphine or alfentanil in adults with severe acute pain (≥ 6/10 on a numerical scale) in the pre-hospital setting.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients aged 18 or over
- Attended by a SMUR team participating in the study and
- Presenting with severe acute pain defined by a numerical scale that he rates as 6/10 or more
- Person affiliated to or benefiting from a social security scheme in France and
- Free informed consent from the patient (possibility of inclusion in an emergency situation and signed consent to continue in the study
You likely can't join if
- Patient having already received treatment with opiates/opioids or agonist-antagonist morphinomimetics, or partial antagonists, in the 6 hours prior to the arrival of the emergency medical services
- Estimated weight >120 kg
- Initial loss of consciousness defined as GCS (Glasgow Coma Scale) < 15
- Arterial hypotension defined as systolic blood pressure < 80 mmHg
- Presence of initial respiratory failure defined as respiratory rate <12 cycles per min and/or oxygen saturation <90% on room air
- Known hypersensitivity to morphine
See the full eligibility criteria
- Patients aged 18 or over
- Attended by a SMUR team participating in the study and
- Presenting with severe acute pain defined by a numerical scale that he rates as 6/10 or more
- Person affiliated to or benefiting from a social security scheme in France and
- Free informed consent from the patient (possibility of inclusion in an emergency situation and signed consent to continue in the study
- Patient having already received treatment with opiates/opioids or agonist-antagonist morphinomimetics, or partial antagonists, in the 6 hours prior to the arrival of the emergency medical services
- Estimated weight >120 kg
- Initial loss of consciousness defined as GCS (Glasgow Coma Scale) < 15
- Arterial hypotension defined as systolic blood pressure < 80 mmHg
- Presence of initial respiratory failure defined as respiratory rate <12 cycles per min and/or oxygen saturation <90% on room air
- Known hypersensitivity to morphine
- Head injury and intracranial hypertension in the absence of controlled ventilation
- Uncontrolled epilepsy
- Known hypersensitivity to excipients present in the composition of morphine and/or alfentanil.
- Known history of chronic respiratory failure, end-stage renal disease, hepatocellular insufficiency or myasthenia gravis
- Pregnant or breast-feeding women (known condition)
- Inability to use a venous or intraosseous approach
- Not affiliated to a Social Security scheme (beneficiary or beneficiary's beneficiary)
- Persons taking part in other research involving a period of exclusion still in progres
- Inability to self-assess pain
- 2nd or 3rd degree burns > 10% of skin surface area
- Indication and possibility of performing a locoregional anaesthetic (e.g. iliofacial block)
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.