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Inhaled corticosteroids in young children with episodic wheezing: a multicenter cluster RCT
EU CTIS ID: 2025-522694-11-00
What this study is testing
To assess the effectiveness of daily ICS for at least 6 weeks and bronchodilators if needed, compared with ICS and bronchodilators during symptoms and only bronchodilators during symptoms on symptom control, exacerbation frequency and quality of life in children aged 1-6 years with EEW treated in general practice, after 1 and 12 months of follow-up.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Children aged 1-6 years (age between ≥1 and <6)
- Visited the general practitioner or out-of-hour services, because of episodic expiratory wheezing, from a second episode onwards
You likely can't join if
- Already known with cystic fibrosis, bronchopulmonary dysplasia or other chronic lung disease
- Premature birth <32 weeks
- Daily inhaled corticosteroids use or oral corticosteroids use within four weeks prior to inclusion
- Current antibiotic use for respiratory complaints
- Already uses chronic medication due to respiratory complaints
- Is under treatment by a (pulmonary) pediatrician because of respiratory complaints
See the full eligibility criteria
- Children aged 1-6 years (age between ≥1 and <6)
- Visited the general practitioner or out-of-hour services, because of episodic expiratory wheezing, from a second episode onwards
- Already known with cystic fibrosis, bronchopulmonary dysplasia or other chronic lung disease
- Premature birth <32 weeks
- Daily inhaled corticosteroids use or oral corticosteroids use within four weeks prior to inclusion
- Current antibiotic use for respiratory complaints
- Already uses chronic medication due to respiratory complaints
- Is under treatment by a (pulmonary) pediatrician because of respiratory complaints
- Their general practitioner (GP) is unwilling to participate in the study
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 0-17 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.