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Pain Relief via Mouthwash or Intravenous Infusion in Mouth Inflammation after Chemotherapy
EU CTIS ID: 2025-522545-22-00
What this study is testing
To evaluate the non-inferiority of esketamine mouthwash compared to intravenous esketamine in reducing mucositis-related pain in patients undergoing hematopoietic stem cell transplantation.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Are 18 years or older.
- Receive high-dose chemotherapy in preparation for a stem cell transplant.
- Develop painful mouth or throat pain (oral mucositis WHO ≥ 2) during admission that are not relieved by regular painkillers. To determine this, the researchers and/or doctors will examine your mouth.
- Can give written consent.
- Speak and understand Dutch or English sufficiently to participate and to complete questionnaires.
You likely can't join if
- Are allergic to (es)ketamine or similar medicines.
- Are simultaneously participating in another study that may interfere with this one.
- Do not speak enough Dutch or English to participate.
- Or if the doctor finds participation unsafe or unsuitable for you.
- Have used (es)ketamine in the past 30 days.
- Have (had) a psychosis or a severe, untreated psychiatric illness.
See the full eligibility criteria
- Are 18 years or older.
- Receive high-dose chemotherapy in preparation for a stem cell transplant.
- Develop painful mouth or throat pain (oral mucositis WHO ≥ 2) during admission that are not relieved by regular painkillers. To determine this, the researchers and/or doctors will examine your mouth.
- Can give written consent.
- Speak and understand Dutch or English sufficiently to participate and to complete questionnaires.
- Are allergic to (es)ketamine or similar medicines.
- Are simultaneously participating in another study that may interfere with this one.
- Do not speak enough Dutch or English to participate.
- Or if the doctor finds participation unsafe or unsuitable for you.
- Have used (es)ketamine in the past 30 days.
- Have (had) a psychosis or a severe, untreated psychiatric illness.
- Have had problems with drug abuse or ketamine misuse.
- Have severe liver problems or an unstable heart condition.
- Have increased intracranial pressure.
- Have an untreated infection in the mouth or throat.
- Cannot safely use mouthwash (for example, due to swallowing problems or drowsiness).
- Are pregnant or breastfeeding.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.