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Post-INFECT: Investigating Neuroinflammation and its effects in post-COVID syndrome
EU CTIS ID: 2025-522349-23-00
What this study is testing
To assess differences between participants with persistent post-COVID complaints and controls without persistent post-COVID complaints in cellular metabolism in the brain as measured with dynamic [18F]FDG PET, structural and functional brain parameters as assessed with MRI, and immune-related blood parameters.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- The subject was diagnosed with mild symptomatic COVID-19, confirmed by a positive PCR for SARS- CoV-2, positive SARS-CoV-2 serology or CO-RADS (COVID-19 Reporting and Data System) 4 or 5 on CT-scan, or antigen quicktest, or had typical symptoms and was part of a household in which another person was tested positive by PCR 2 weeks before or after the first day of illness
- The subject is at least one year after being diagnosed with COVID-19
- Subjects with persistent post-COVID complaints experience severe levels of fatigue (≥ 35) on the fatigue subscale of the Checklist Individual Strength [CIS-fatigue]) and/or difficulty concentrating (≥18) on the concentration subscale of the Checklist Individual Strength [CIS-concentration]. Control subjects without persistent complaints experiences no fatigue (<35) on the CIS-fatigue and no difficulty concentrating (<18) on the CIS-concentration
- The subject is in the range 30-65 years of age
- The subject has sufficient command of the Dutch language
You likely can't join if
- The subject is unable to lay still for scanning due to claustrophobia, severe back pain or trypanophobia (fear of needles)
- The subject is of female sex with childbearing potential and not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception. Females of childbearing potential must orally and in writing confirm not to be pregnant or breastfeeding at the time of screening and at the day of the PET scan
- The subject has an already known psychiatric, somatic or neurodegenerative condition that can explain his/her complaints
- The subject is actively using anti-inflammatory drugs
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.