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Efficacy of sphenopalatine block compared to blood patch in the management of post-dural puncture syndrome.
EU CTIS ID: 2025-522168-34-00
What this study is testing
Evaluate the effectiveness of the sphenopalatine block for the management of post-dural puncture headaches compared to the current standard treatment, the blood patch, within 7 days.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Presence of post-dural-puncture headaches meeting the criteria of the International Classification of Headache Disorders (ICHD-3)
- Present persistent headaches after 24 hours of conservative treatment.
- Patients older than 18 years
- Patients who have given their informed consent
- Patients affiliated with a Social Security scheme.
You likely can't join if
- Patients under protection measures (guardianship or curatorship) or deprived of liberty (prisoners)
- Pregnant patients
- Patients presenting an allergy to one of the medications used in the protocol
- Patients presenting with a clinical picture of atypical post-dural puncture headache that may suggest a post-puncture complication (consciousness disorder, focal neurological deficit, epilepsy, visual disturbance...)
- Patients presenting with chronic headaches requiring preventive treatment
- Patients with a history of spine surgery preventing the realization of the blood patch
See the full eligibility criteria
- Presence of post-dural-puncture headaches meeting the criteria of the International Classification of Headache Disorders (ICHD-3)
- Present persistent headaches after 24 hours of conservative treatment.
- Patients older than 18 years
- Patients who have given their informed consent
- Patients affiliated with a Social Security scheme.
- Patients under protection measures (guardianship or curatorship) or deprived of liberty (prisoners)
- Pregnant patients
- Patients presenting an allergy to one of the medications used in the protocol
- Patients presenting with a clinical picture of atypical post-dural puncture headache that may suggest a post-puncture complication (consciousness disorder, focal neurological deficit, epilepsy, visual disturbance...)
- Patients presenting with chronic headaches requiring preventive treatment
- Patients with a history of spine surgery preventing the realization of the blood patch
- Patients with a contraindication for the blood patch procedure (local or systemic infection, platelets < 80 G/L, coagulation disorder, progressive neurological disease)
- Patients with a contraindication for performing the sphenopalatine block (nasal polyps, rhinopharyngitis, deviation of the nasal septum).
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.