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Clinical trial evaluating the biological activity of a new drug identified as prifetrastat (PF-07248144), combined with fulvestrant for the treatment of patients with hormone receptor positive (HR+) and HER2 negative (HER2-) breast cancer extended to other organs
EU CTIS ID: 2025-521982-29-00
What this study is testing
The primary objective of the study is to assess the effect of prifetrastat with fulvestrant on ctDNA-based mutation burden among patients with HR+/HER2- mBC.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patient must have signed the written informed consent prior to any study specific screening procedures.
- Women of childbearing potential must have a negative serum pregnancy test (with a sensitivity of at least 25 mIU/mL) result within 3 days of enrolment
- Men or women of childbearing potential must agree to the use of effective contraceptive for the study duration and for at least 2 years after the last dose of study treatment for women, and at least 5 months after the last dose for men.
- Adult participants age ≥18 years.
- Patients must be affiliated to a Social Security System (or equivalent).
- Patients must be willing and able to comply with the protocol for the duration of the study including scheduled visits, treatment plan, laboratory tests and other study procedures.
You likely can't join if
- Participants with known symptomatic brain metastases requiring steroids. Participants with previously diagnosed brain metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued corticosteroid treatment for these metastases for at least 3 weeks and are neurologically stable for 2 months (requires MRI confirmation).
- Current use or anticipated need for food or drugs that are known moderate or strong CYP3A4/5 inhibitors, including their administration within 10 days or 5 half-lives of the CYP3A4/5 inhibitor, whichever is longer prior to first dose of study intervention (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CYP3A4/5 inhibitors).
- Current use or anticipated need for food or drugs that are known strong CYP3A4/5 inducers, including their administration within 10 days or 5 half-lives of the CYP3A4/5 inducer, whichever is longer prior to the first dose of study intervention (see Appendix 7 for a non-exhaustive list of exemplary strong/moderate CYP3A4/5 inducers).
- Participants with advanced/metastatic, symptomatic, visceral spread, that are at risk of life-threatening complications in the short term (including participants with massive uncontrolled effusions [pleural, pericardial, peritoneal], pulmonary lymphangitis, and over 50% liver involvement). Note: Participants with indwelling catheter for drainage, or requirement for drainage no more frequently than once a month will be allowed.
- Current use or anticipated need for food or drugs that are known moderate/strong CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone), including their administration within [10 days or 5 half-lives of the CYP2C9 inhibitor, whichever is longer] prior to first dose of investigational product (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CYP2C9 inhibitors).
- Current use or anticipated need for drugs that are known moderate/strong CYP2C9 inducers (e.g., carbamazepine, rifampin), including their administration within [10 days or 5 half-lives of the CYP2C9 inducer, whichever is longer] prior to the first dose of investigational product (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CY2C9 inducers).
See the full eligibility criteria
Who can join
- Patient must have signed the written informed consent prior to any study specific screening procedures.
- Women of childbearing potential must have a negative serum pregnancy test (with a sensitivity of at least 25 mIU/mL) result within 3 days of enrolment
- Men or women of childbearing potential must agree to the use of effective contraceptive for the study duration and for at least 2 years after the last dose of study treatment for women, and at least 5 months after the last dose for men.
- Adult participants age ≥18 years.
- Patients must be affiliated to a Social Security System (or equivalent).
- Patients must be willing and able to comply with the protocol for the duration of the study including scheduled visits, treatment plan, laboratory tests and other study procedures.
- Histological or cytological diagnosis of advanced or metastatic ER+HER2- breast cancer.
- Participants must have progressive disease (PD) after receiving prior CDK4/6 inhibitor in one of the following settings as described below: - CDK4/6i plus endocrine therapy (ET) in the advanced or metastatic breast cancer setting; or - CDK4/6i plus ET in adjuvant setting with documented PD or recurrence during or within 12 months after the last dose of CDK4/6i. In addition, participants must not have received more than 3 prior lines of systemic therapies (adjuvant CDK4/6i included), including up to 2 lines of cytotoxic chemotherapy for visceral disease in advanced or metastatic setting. Note that prior treatment with fulvestrant is permitted.
- Participants must have documentation of ER-positive tumor (≥10% positive stained cells) based on most recent tumor biopsy utilizing an assay consistent with local standards.
- Participants must have documentation of HER2-negative tumor, defined as immunohistochemistry (IHC) score 0 or 1+, or an IHC score of 2+ with a negative in situ hybridization (ISH) (HER2/CEP17 ratio <2 or, for single probe assessment, HER2 copy number <4).
- Female participants with premenopausal status (see section 5.8.4) must be willing to undergo medically induced menopause by treatment with approved LHRH agonist such as goserelin, leuprolide or equivalent agents to induce chemical menopause
- ECOG Performance Status PS 0 or 1
- Participants must have at least 1 measurable lesion as defined by RECIST version 1.1 that has not been previously irradiated.
- Participants must present with a metastatic site easily accessible to a biopsy procedure and be a non-bone and non-irradiated site.
- Adequate serum potassium , serum magnesium and serum calcium (>LLN)
- Expected survival of more than 3 months.
- Adequate bone marrow function, including: a. ANC ≥1,500/mm3 or ≥1.5 x 109/L; b. Platelets ≥100,000/mm3 or ≥100 x 109/L; c. Hemoglobin ≥9 g/dL
- Adequate renal function, including serum creatinine ≤1.5 x ULN or estimated creatinine clearance GFR ≥50 mL/min as calculated using the method standard for the institution. In equivocal cases, a 24-hour urine collection test can be used to estimate creatinine clearance more accurately
- Adequate liver function, including: a. Total serum bilirubin ≤1.5 x ULN unless the participant has documented Gilbert syndrome; b. AST and ALT ≤2.5 x ULN; AST and ALT ≤5.0 x ULN if there is liver involvement. Alkaline phosphatase ≤ 2.5 × ULN (≤ 5 × ULN in case of liver or bone metastasis)
- Adequate blood clotting function: International Normalized Ratio (INR)/Prothrombin Time (PT) and either partial thromboplastin Time (PTT) or activated Partial Thromboplastin Time (aPTT) ≤1.5 x ULN
- Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1 except for AEs not constituting a safety risk by investigator judgment
- Participants must consent to the use of their archived and/or collected tumor specimen, as well as blood samples, as detailed in the protocol, for future scientific research which includes, but is not limited to DNA, RNA, and protein-based biomarker detection.
What rules you out
- Participants with known symptomatic brain metastases requiring steroids. Participants with previously diagnosed brain metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued corticosteroid treatment for these metastases for at least 3 weeks and are neurologically stable for 2 months (requires MRI confirmation).
- Current use or anticipated need for food or drugs that are known moderate or strong CYP3A4/5 inhibitors, including their administration within 10 days or 5 half-lives of the CYP3A4/5 inhibitor, whichever is longer prior to first dose of study intervention (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CYP3A4/5 inhibitors).
- Current use or anticipated need for food or drugs that are known strong CYP3A4/5 inducers, including their administration within 10 days or 5 half-lives of the CYP3A4/5 inducer, whichever is longer prior to the first dose of study intervention (see Appendix 7 for a non-exhaustive list of exemplary strong/moderate CYP3A4/5 inducers).
- Participants with advanced/metastatic, symptomatic, visceral spread, that are at risk of life-threatening complications in the short term (including participants with massive uncontrolled effusions [pleural, pericardial, peritoneal], pulmonary lymphangitis, and over 50% liver involvement). Note: Participants with indwelling catheter for drainage, or requirement for drainage no more frequently than once a month will be allowed.
- Current use or anticipated need for food or drugs that are known moderate/strong CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone), including their administration within [10 days or 5 half-lives of the CYP2C9 inhibitor, whichever is longer] prior to first dose of investigational product (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CYP2C9 inhibitors).
- Current use or anticipated need for drugs that are known moderate/strong CYP2C9 inducers (e.g., carbamazepine, rifampin), including their administration within [10 days or 5 half-lives of the CYP2C9 inducer, whichever is longer] prior to the first dose of investigational product (see Appendix 8 for a non-exhaustive list of exemplary strong/moderate CY2C9 inducers).
- Patient is currently pregnant, breastfeeding, or planning to become pregnant.
- Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator’s judgment, make the participant inappropriate for the study.
- Patient unwilling or unable to comply with the medical follow-up required by the trial because of geographic, familial, social, or psychological reasons.
- Person deprived of their liberty or under protective custody or guardianship.
- Participants with any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ. Other indolent cancers that do not interfere with assessment of primary cancer under study may be allowed with prior sponsor approval.
- Baseline 12 -lead ECG that demonstrates clinically relevant abnormalities that may affect participant safety or interpretation of study results (e.g., baseline QTc interval >450 msec for men, or >470 msec for women, complete LBBB, signs of an acute myocardial infarction, ST changes suggestive of active myocardial ischemia, second- or third- degree AV block, or serious bradyarrhythmia or tachyarrhythmias). If the baseline uncorrected QT interval is >470 msec, this interval should be rate corrected using the Fridericia method and the resulting QTcF- should be used for decision making and reporting. If QTcF exceeds >450 msec for men, or 470 msec for women, or QRS exceeds 120 msec, the ECG should be repeated 2 more times and the average of the 3 QTcF or QRS values should be used to determine the participant’s eligibility. Computer -interpreted ECGs should be overread by a physician experienced in reading ECGs before excluding participants. Cases must be discussed in detail with sponsor to judge eligibility
- Major surgery within 3 weeks prior to randomization.
- Radiation therapy within 3 weeks prior to randomization.
- Systemic anti-cancer therapy within 3 weeks prior to randomization. If the last immediate anti-cancer treatment contained an antibody-based agent(s) (approved or investigational), then an interval of 28 days or 5 half-lives (whichever is shorter) of the agent(s) prior to receive the study intervention treatment is required.
- Prior irradiation to >25% of the bone marrow.
- Participants with active, uncontrolled bacterial, fungal, or viral infection, including (but not limited to) HBV, HCV, known HIV or AIDS related illness. HIV seropositive subjects who are healthy and low risk for AIDS-related outcomes could be considered eligible. Active HBV is defined as HBsAg reactive, active HCV is defined as HCV RNA [qualitative] detected. Subjects who have been curatively treated for hepatitis C infection are permitted if they have documented sustained virologic response of 12 weeks. Eligibility criteria for HIV-positive subjects should be evaluated and discussed with sponsor’s medical monitor and will be based on current and past CD4 and T-cell counts, history (if any) of AIDS-defining conditions (e.g., opportunistic infections), and status of HIV treatment. Also, the potential for drug-drug interactions will be taken into consideration. In equivocal cases, with positive serology, those participants with a negative viral load are potentially eligible provided the other entry criteria are met.
- Unmanageable ascites (limited medical treatment to control ascites is permitted, but all participants with ascites require review by sponsor).
- Current use or anticipated need for pimozide (Orap®) and cisapride (Prepulsid®).
- Any of the following in the previous 6 months: myocardial infarction, long QT syndrome, Torsade de Pointes, clinically important atrial or ventricular arrhythmias (including sustained ventricular tachyarrhythmia and ventricular fibrillation), serious conduction system abnormalities (eg, bifascicular block [defined as right bundle branch and left anterior or posterior hemiblock], 3rd degree AV block), unstable angina, coronary/peripheral artery bypass graft, symptomatic CHF, New York Heart Association class III or IV, cerebrovascular accident, transient ischemic attack, symptomatic pulmonary embolism, and/or other clinical significant episode of thrombo embolic disease and ongoing cardiac dysrhythmias of NCI CTCAE ≥Grade 2. For Grade 2 atrial fibrillation, may be considered eligible with sponsor approval (e.g if improved to Grade 1 with non-urgent medical intervention or chronic Grade 2 atrial fibrillation with good rate control with non-urgent medical intervention). If a participant has a cardiac rhythm device/pacemaker placed and QTcF >470 msec, the participant can be considered eligible. Participants with cardiac rhythm device/pacemaker must be discussed in detail with sponsor’s medical monitor to judge eligibility
- Therapeutic anticoagulation.
- Hypertension that cannot be controlled by optimal medical therapy (eg, ≥160/100 mmHg).
- Participation in other studies involving investigational drug(s) within 3 weeks prior to study entry (or 5 half-lives prior to first dose of study intervention). Participation in observational or in long term follow-up of other studies is allowed if no procedures which may interfere with the interpretation of study results will be performed.
- Known or suspected hypersensitivity or severe allergy to active ingredient/excipients of study drug(s) such as lactose.
- Prior treatment with prifetrastat. Note that prior treatment with fulvestrant is permitted
- Active inflammatory GI disease, refractory and unresolved chronic diarrhea or previous gastric resection, lap band surgery or other GI conditions and surgeries that may significantly alter the absorption of prifetrastat. Gastroesophageal reflux disease under treatment is allowed.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.