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Efficacy of MIrikizumab to achieve traNsmural healing in patiENTs with Crohn’s Disease : EMINENT CD
EU CTIS ID: 2025-521889-95-00
What this study is testing
To describe the efficacy of mirikizumab therapy to achieve transmural response in patients with CD.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients with CD
- ≥ 18 years-old ≤ 75 years old
- Symptomatic CD according to PRO-2 (stool > 3 or abdominal pain score > 1)
- Transmural inflammation on baseline MRI (C-score > 0.5 in at least one segment)
You likely can't join if
- Prior exposure to anti-p19 biological therapy
- No health insurance
- Pregnant or lactating women
- Patients already included in biomedical research other than an observational study (e.g., registry, cohort)
- Concomitant Clostridioides difficile infection
- HIV infection
See the full eligibility criteria
- Patients with CD
- ≥ 18 years-old ≤ 75 years old
- Symptomatic CD according to PRO-2 (stool > 3 or abdominal pain score > 1)
- Transmural inflammation on baseline MRI (C-score > 0.5 in at least one segment)
- Prior exposure to anti-p19 biological therapy
- No health insurance
- Pregnant or lactating women
- Patients already included in biomedical research other than an observational study (e.g., registry, cohort)
- Concomitant Clostridioides difficile infection
- HIV infection
- Patient under guardianship, curatorship or safeguard of justice
- Exposure to more than 1 class of advanced therapies at a dose approved for the treatment of Crohn's disease (janus kinase [JAK] inhibitors, infliximab, adalimumab, certolizumab pegol, vedolizumab, ustekinumab, or approved biosimilars for these agents
- Contra-indication to mirikizumab
- Definitive ostomy
- Colectomy with IPAA
- Isolated or uncontrolled perianal lesions
- Severe obstructive symptoms
- Intra-abdominal abscess
- Contra-indication to MRI
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.